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Am J Physiol Regul Integr Comp Physiol 266: R413-R418, 1994;
0363-6119/94 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 2 413-R418, Copyright © 1994 by American Physiological Society

ARTICLES

Effects of 2-buten-4-olide, an endogenous satiety substance, on plasma glucose, corticosterone, and catecholamines

I. Matsumoto, Y. Oomura, H. Nishino, S. Nemoto, S. Aou and T. Aikawa
Department of Physiology, Nagasaki University School of Medicine, Nagasaki, Japan.

Effects of 2-buten-4-olide (2-B4O), an endogenous satiety substance, on levels of plasma glucose, corticosterone, and catecholamines were examined in fed, conscious, and unrestrained rats. A vascular indwelling catheter was inserted into the right atrium of the animal from the jugular vein 1 wk before the experiment. Injection of 2-B4O and blood sampling were performed through the catheter in an unanesthetized condition. The levels of plasma glucose, corticosterone, epinephrine, and norepinephrine increased significantly for 2 h after the start of intravenous injection of 2-B4O in a dose-dependent manner. The increases in glucose and catecholamines induced by 2-B4O injection were abolished by bilateral splanchnicotomy (SPX) but not by pretreatment with anti-corticotropin-releasing factor (CRF) antibody. The increase in corticosterone was abolished not by the SPX but by pretreatment with anti-CRF antibody. These findings suggest that 2-B4O, endogenously produced during food deprivation, may facilitate sympathoadrenal and hypothalamopituitary-adrenal functions through the central nervous system.


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