AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 2 458-R465, Copyright © 1994 by American Physiological Society

ARTICLES

Renin-angiotensin, arterial blood pressure, and salt appetite in rats

R. L. Thunhorst and A. K. Johnson
Department of Psychology, University of Iowa, Iowa City 52242-1407.

Simultaneous administration of the diuretic furosemide (10 mg/kg sc) and a low dose of the angiotensin-converting enzyme inhibitor captopril (5 mg/kg sc) reduced mean arterial blood pressure (MAP) and increased ingestion of water and 0.3 M NaCl within 2 h. Administration of either agent alone did not reduce MAP or cause significant fluid intakes. The increased ingestion of water and saline after furosemide plus captopril 1) was not due to increased excretion of water and sodium compared with losses after furosemide alone, 2) was abolished by the AT1-receptor blocker, losartan (10 mg/kg sc), and 3) was abolished by administration of a greater dose of captopril (100 mg/kg sc). Intravenous infusion of phenylephrine (3-4 micrograms.kg-1 x min-1) prevented the reduction in MAP after furosemide plus captopril and blunted the saline intake but not water intake. Simultaneous administration of the vasodilator minoxidil and captopril also stimulated robust salt appetite in association with reduced MAP. It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses.

This article has been cited by other articles:

				J. I. F. De Gobbi, J. V. Menani, T. G. Beltz, R. F. Johnson, R. L. Thunhorst, and A. K. Johnson Right atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetite J. Physiol., August 1, 2008; 586(15): 3719 - 3729. [Abstract] [Full Text] [PDF]

				C. V. Pastuskovas, M. D. Cassell, A. K. Johnson, and R. L. Thunhorst Increased cellular activity in rat insular cortex after water and salt ingestion induced by fluid depletion Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1119 - R1125. [Abstract] [Full Text] [PDF]

				F. W. Flynn, T. R. Kirchner, and M. E. Clinton Brain vasopressin and sodium appetite Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1236 - R1244. [Abstract] [Full Text] [PDF]

				R. L. Thunhorst and A. K. Johnson Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1726 - R1733. [Abstract] [Full Text] [PDF]

				J. I. Fratucci De Gobbi, L. A. De Luca Jr., A. K. Johnson, and J. V. Menani Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1301 - R1307. [Abstract] [Full Text] [PDF]

				D. A. Fitts, E. M. Starbuck, and A. Ruhf Circumventricular organs and ANG II-induced salt appetite: blood pressure and connectivity Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2277 - R2286. [Abstract] [Full Text] [PDF]

				J. V. Menani, L. A. De Luca Jr., R. L. Thunhorst, and A. K. Johnson Hindbrain serotonin and the rapid induction of sodium appetite Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R126 - R131. [Abstract] [Full Text] [PDF]

				R. L. Thunhorst, T. G. Beltz, and A. K. Johnson Effects of subfornical organ lesions on acutely induced thirst and salt appetite Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R56 - R65. [Abstract] [Full Text] [PDF]

				J. V. Menani and A. K. Johnson Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1431 - R1437. [Abstract] [Full Text] [PDF]

				J. T. FITZSIMONS Angiotensin, Thirst, and Sodium Appetite Physiol Rev, July 1, 1998; 78(3): 583 - 686. [Abstract] [Full Text] [PDF]

				R. L. Thunhorst, Z. Xu, M. Z. Cicha, A. M. Zardetto-Smith, and A. K. Johnson Fos expression in rat brain during depletion-induced thirst and salt appetite Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1807 - R1814. [Abstract] [Full Text] [PDF]

				J. V. Menani, L. A. De Luca Jr., and A. K. Johnson Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R555 - R560. [Abstract] [Full Text] [PDF]