AJP - Regu AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 266: R1371-R1382, 1994;
0363-6119/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Himms-Hagen, J.
Right arrow Articles by Claus, T. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Himms-Hagen, J.
Right arrow Articles by Claus, T. H.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 4 1371-R1382, Copyright © 1994 by American Physiological Society

ARTICLES

Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats

J. Himms-Hagen, J. Cui, E. Danforth Jr, D. J. Taatjes, S. S. Lang, B. L. Waters and T. H. Claus
Department of Biochemistry, University of Ottawa, Ontario, Canada.

The objective was to assess the effect of a new, highly selective beta 3-adrenergic agonist, CL-316,243 (CL) (J. D. Bloom, M. D. Dutia, B. D. Johnson, A. Wissner, M. G. Burns, E. E. Largis, J. A. Dolan, and T. H. Claus., J. Med. Chem. 35: 3081, 1992), on energy balance and brown and white adipose tissues (BAT and WAT, respectively) in young rats eating a high-fat diet to induce obesity. Chronic treatment with CL increased body temperature and 24-h energy expenditure, mainly by increasing resting metabolic rate. Food intake was not altered but carcass fat was reduced. Interscapular BAT was markedly hypertrophied, with three- to fourfold increases in the content of uncoupling protein (UCP) and cytochrome oxidase. Quantitative immunoelectron microscopy of interscapular BAT of CL-treated rats showed smaller mitochondria with an unchanged total amount of UCP per mitochondrion. The relative frequency of the four major cell types in BAT (mature brown adipocytes, preadipocytes, interstitial cells, endothelial cells) was not altered. The CL-induced hypertrophy differed from that induced by chronic stimulation by endogenous norepinephrine (as in cold-adaptation) in absence of hyperplasia (there was a slightly reduced DNA content), absence of an increase in the thyroxine (T4) 5'-deiodinase activity, and absence of a selective increase in UCP concentration. WAT depots weighed less and had fewer cells (lower DNA content) in the CL-treated rats. Some multilocular adipocytes appeared in these normally almost exclusively unilocular WAT depots (mesenteric, inguinal, epididymal, retroperitoneal). We conclude that CL not only promotes BAT mitochondrial proliferation and thermogenesis and overall energy expenditure and leanness, but also retards the development of WAT hyperplasia during the early stage of diet-induced obesity.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. D. Mulligan, A. A. Gonzalez, A. M. Stewart, H. V. Carey, and K. W. Saupe
Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse
J. Physiol., April 15, 2007; 580(2): 677 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. Kim, P. A. Pennisi, O. Gavrilova, S. Pack, W. Jou, J. Setser-Portas, J. East-Palmer, Y. Tang, V. C. Manganiello, and D. LeRoith
Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice
Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1227 - E1236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K.-i. Inokuma, Y. Okamatsu-Ogura, A. Omachi, Y. Matsushita, K. Kimura, H. Yamashita, and M. Saito
Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E1014 - E1021.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. CANNON and J. NEDERGAARD
Brown Adipose Tissue: Function and Physiological Significance
Physiol Rev, January 1, 2004; 84(1): 277 - 359.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Masuda, S. Haramizu, K. Oki, K. Ohnuki, T. Watanabe, S. Yazawa, T. Kawada, S.-i. Hashizume, and T. Fushiki
Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog
J Appl Physiol, December 1, 2003; 95(6): 2408 - 2415.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. G. Granneman, M. Burnazi, Z. Zhu, and L. A. Schwamb
White adipose tissue contributes to UCP1-independent thermogenesis
Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1230 - E1236.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
A. A. Coulter, C. M. Bearden, X. Liu, R. A. Koza, and L. P. Kozak
Dietary fat interacts with QTLs controlling induction of Pgc-1{alpha} and Ucp1 during conversion of white to brown fat
Physiol Genomics, July 7, 2003; 14(2): 139 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
T. M Larsen, S. Toubro, M. A van Baak, K. M Gottesdiener, P. Larson, W. H. Saris, and A. Astrup
Effect of a 28-d treatment with L-796568, a novel {beta}3-adrenergic receptor agonist, on energy expenditure and body composition in obese men
Am. J. Clinical Nutrition, October 1, 2002; 76(4): 780 - 788.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. S. Rim and L. P. Kozak
Regulatory Motifs for CREB-binding Protein and Nfe2l2 Transcription Factors in the Upstream Enhancer of the Mitochondrial Uncoupling Protein 1 Gene
J. Biol. Chem., September 6, 2002; 277(37): 34589 - 34600.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Collins, W. Cao, K. W. Daniel, T. M. Dixon, A. V. Medvedev, H. Onuma, and R. Surwit
Adrenoceptors, Uncoupling Proteins, and Energy Expenditure
Experimental Biology and Medicine, December 1, 2001; 226(11): 982 - 990.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. A. Schreyer, D. E. Cummings, G. S. McKnight, and R. C. LeBoeuf
Mutation of the RII{beta} Subunit of Protein Kinase A Prevents Diet-Induced Insulin Resistance and Dyslipidemia in Mice
Diabetes, November 1, 2001; 50(11): 2555 - 2562.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
G. J. Hom, M. J. Forrest, T. J. Bach, E. Brady, M. R. Candelore, M. A. Cascieri, D. J. Fletcher, M. H. Fisher, S. A. Iliff, R. Mathvink, et al.
{beta}3-Adrenoceptor Agonist-Induced Increases in Lipolysis, Metabolic Rate, Facial Flushing, and Reflex Tachycardia in Anesthetized Rhesus Monkeys
J. Pharmacol. Exp. Ther., April 1, 2001; 297(1): 299 - 307.
[Abstract] [Full Text]

Home page
 DiabetesHome page
T. Masaki, H. Yoshimatsu, S. Chiba, T. Watanabe, and T. Sakata
Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice
Diabetes, February 1, 2001; 50(2): 376 - 384.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
L. P. Kozak
Genetic Studies of Brown Adipocyte Induction
J. Nutr., December 1, 2000; 130 (12): 3132S - 3133S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Himms-Hagen, A. Melnyk, M. C. Zingaretti, E. Ceresi, G. Barbatelli, and S. Cinti
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Am J Physiol Cell Physiol, September 1, 2000; 279(3): C670 - C681.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Barzilai, L. She, L. Liu, J. Wang, M. Hu, P. Vuguin, and L. Rossetti
Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
Am J Physiol Endocrinol Metab, August 1, 1999; 277(2): E291 - E298.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. J. Soeder, S. K. Snedden, W. Cao, G. J. Della Rocca, K. W. Daniel, L. M. Luttrell, and S. Collins
The {beta}3-Adrenergic Receptor Activates Mitogen-activated Protein Kinase in Adipocytes through a Gi-dependent Mechanism
J. Biol. Chem., April 23, 1999; 274(17): 12017 - 12022.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Liu, G. B. Karkanias, J. C. Morales, M. Hawkins, N. Barzilai, J. Wang, and L. Rossetti
Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes
J. Biol. Chem., November 20, 1998; 273(47): 31160 - 31167.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. J. Bartness and M. Bamshad
Innervation of mammalian white adipose tissue: implications for the regulation of total body fat
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1399 - R1411.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Liu, F. Perusse, and L. J. Bukowiecki
Mechanisms of the antidiabetic effects of the beta 3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1212 - R1219.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. FLOREZ-DUQUET and R. B. McDONALD
Cold-Induced Thermoregulation and Biological Aging
Physiol Rev, April 1, 1998; 78(2): 339 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Yoshida, T. Umekawa, K. Kumamoto, N. Sakane, A. Kogure, M. Kondo, Y. Wakabayashi, T. Kawada, I. Nagase, and M. Saito
beta 3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers
Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E469 - E475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Stefl, A. Janovska, Z. Hodny, M. Rossmeisl, M. Horakova, I. Syrovy, J. Bemova, B. Bendlova, and J. Kopecky
Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice
Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E527 - E533.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Grujic, V. S. Susulic, M.-E. Harper, J. Himms-Hagen, B. A. Cunningham, B. E. Corkey, and B. B. Lowell
beta 3-Adrenergic Receptors on White and Brown Adipocytes Mediate beta 3-Selective Agonist-induced Effects on Energy Expenditure, Insulin Secretion, and Food Intake. A STUDY USING TRANSGENIC AND GENE KNOCKOUT MICE
J. Biol. Chem., July 11, 1997; 272(28): 17686 - 17693.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. Walston, K. Silver, C. Bogardus, W. C. Knowler, F. S. Celi, S. Austin, B. Manning, A. D. Strosberg, M. P. Stern, N. Raben, et al.
Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the {beta}3-Adrenergic-Receptor Gene
N. Engl. J. Med., August 10, 1995; 333(6): 343 - 347.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Cao, L. M. Luttrell, A. V. Medvedev, K. L. Pierce, K. W. Daniel, T. M. Dixon, R. J. Lefkowitz, and S. Collins
Direct Binding of Activated c-Src to the beta 3-Adrenergic Receptor Is Required for MAP Kinase Activation
J. Biol. Chem., December 1, 2000; 275(49): 38131 - 38134.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Koza, S. M. Hohmann, C. Guerra, M. Rossmeisl, and L. P. Kozak
Synergistic Gene Interactions Control the Induction of the Mitochondrial Uncoupling Protein (Ucp1) Gene in White Fat Tissue
J. Biol. Chem., October 27, 2000; 275(44): 34486 - 34492.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. M. Dixon, K. W. Daniel, S. R. Farmer, and S. Collins
CCAAT/Enhancer-binding Protein alpha Is Required for Transcription of the beta 3-Adrenergic Receptor Gene during Adipogenesis
J. Biol. Chem., January 5, 2001; 276(1): 722 - 728.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online