AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 6 1928-R1932, Copyright © 1994 by American Physiological Society
Factors influencing compensatory feeding during parenteral nutrition in rats
J. L. Beverly, Z. J. Yang and M. M. Meguid
Department of Surgery, State University of New York-Health Science Center, University Hospital, Syracuse 13210.
During parenteral nutrition (PN) there is an incomplete compensatory
decrease in oral caloric intake. The effects of two factors influencing
nutrient utilization, diurnal timing of PN infusion and composition of
available diet, on compensatory feeding were investigated in male rats
receiving 100% of daily caloric need as PN (PN-100). Compensation for
infused calories increased from 70 to 80% (P < 0.05) when the timing of
infused kilocalories more closely matched diurnal pattern of oral
kilocalories intake (e.g., 75% kcal daily during the dark phase, 25% during
the light phase). There was a similar degree of compensation when the diet
and PN-100 had the same caloric distribution (50% kcal from carbohydrate,
30% from fat, and 20% from protein). Adjusting the diurnal timing of
infused calories and diet composition concurrently further increased
compensation for infused calories from 70 to 90% (P < 0.05). In the rat
PN-100 model, compensation for infused calories is improved by adjusting
the temporal pattern of infusions and diet composition.
