AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 1 38-R43, Copyright © 1994 by American Physiological Society

ARTICLES

Hypothalamic linkage in stress-induced hypocalcemia, gastric damage, and emotional behavior in rats

S. Aou, J. Ma, T. Hori and N. Tashiro
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

The effects of hypothalamic lesions on stress-induced hypocalcemia, gastric damage, and swim test-evoked behavior were examined in rats. Bilateral lesions of the ventromedial nucleus in the hypothalamus (VMH) eliminated water-restraint stress-induced hypocalcemia and attenuated any gastric damage compared with those in the sham-operated rats. In contrast, lesions in the paraventricular nucleus (PVN) exacerbated both the stress-induced hypocalcemia and gastric lesions in comparison with those in the control rats. In a forced-swimming test, the VMH-lesioned rats showed a significantly shorter time of immobility as well as a longer duration of struggling than the control rats, respectively, while the PVN-lesioned animals spent a longer time in immobility and a shorter period struggling than the control rats. These results suggest that the VMH has an accelerative action in stress-induced hypocalcemia, gastric lesions, and behavioral despair, while the PVN has an opposite effect.

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