AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 2 616-R618, Copyright © 1994 by American Physiological Society
2-deoxy-D-glucose suppresses food intake through activation of hypothalamic histamine in rats
T. Sakata, Y. Tamari, M. Kang and H. Yoshimatsu
Department of Internal Medicine I, School of Medicine, Oita Medical University, Japan.
The aim of this experiment was to demonstrate whether brain histamine
contributes to delayed suppression of food intake after administration of
2-deoxy-D-glucose (2-DG). Food intake decreased significantly for 48 h
after infusion of 2-DG into the rat third cerebroventricle. This delayed
decrease in food intake was abolished by depletion of neuronal histamine by
intraperitoneal pretreatment with alpha-fluoromethylhistidine (160
mumol/rat), a suicide inhibitor of a histamine-synthesizing enzyme.
Intracerebroventricular infusion of 24 mumol 2-DG accelerated turnover rate
of hypothalamic histamine. These results indicate that the delayed feeding
suppression by 2-DG is modulated through histaminergic neurons in the
hypothalamus. This histaminergic response may be related, at least in part,
to homeostatic control of energy metabolism in the brain.
