| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 4 965-R973, Copyright © 1994 by American Physiological Society
ARTICLES |
A. M. Schreihofer, E. M. Stricker and A. F. Sved
Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260.
The present study examined the hypothesis that hypovolemia stimulates vasopressin (VP) secretion by removing tonic inhibitory baroreceptor input. Serial hemorrhage (4 samples of 2 ml/300 g body wt taken every 10 min) increased plasma VP levels in conscious rats devoid of cardiac and arterial baroreceptor reflex responses due to chronic bilateral lesions of nucleus tractus solitarius (NTS). The VP response to hemorrhage was similar to that seen in control rats and chronic sinoaortic-denervated (SAD) rats. After subcutaneous injection of 30% polyethylene glycol, NTS-lesioned rats, SAD rats, and control rats had elevated VP levels that correlated with the induced depletion of plasma volume. Additionally, in alpha-chloralose-anesthetized control rats, chronic SAD rats, and chronic NTS-lesioned rats, bilateral vagotomy had minimal effects on basal VP levels, and vagotomy in chronic NTS-lesioned rats did not prevent hemorrhage-evoked increases in VP secretion. These results do not support the idea that hemorrhage-induced VP secretion occurs through reduction in tonic inhibitory baroreceptor input. Instead, neither cardiac nor arterial baroreceptor input appears to be necessary for hypovolemia-induced VP secretion in rats.
This article has been cited by other articles:
|
|
 |
|
  M. J. McKinley, L. L. Walker, T. Alexiou, A. M. Allen, D. J. Campbell, R. Di Nicolantonio, B. J. Oldfield, and D. A. Denton Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice lacking angiotensin Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1533 - R1543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ciriello, L. P. Solano-Flores, M. P. Rosas-Arellano, G. J. Kirouac, and T. Babic Medullary pathways mediating the parasubthalamic nucleus depressor response Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1276 - R1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Geerling and A. D. Loewy Sodium depletion activates the aldosterone-sensitive neurons in the NTS independently of thirst Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1338 - R1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Stocker, M. E. Wilson, C. J. Madden, U. Lone, and A. F. Sved Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R59 - R67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Osei-Owusu and K. Scrogin Role of the arterial baroreflex in 5-HT1A receptor agonist-mediated sympathoexcitation following hypotensive hemorrhage Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1337 - R1344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Schreihofer, S. Ito, and A. F. Sved Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1746 - R1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xu and A. F. Sved Acute sympathoexcitatory action of angiotensin II in conscious baroreceptor-denervated rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R451 - R459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Thrasher and L. C. Keil Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R1035 - R1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Schreihofer, E. M. Stricker, and A. F. Sved Nucleus of the solitary tract lesions enhance drinking, but not vasopressin release, induced by angiotensin Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R239 - R247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, A. F. Sved, and E. M. Stricker Vasopressin and oxytocin release evoked by NaCl loads are selectively blunted by area postrema lesions Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R732 - R740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Schreihofer, B. K. Anderson, J. C. Schiltz, L. Xu, A. F. Sved, and E. M. Stricker Thirst and salt appetite elicited by hypovolemia in rats with chronic lesions of the nucleus of the solitary tract Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R251 - R258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Thrasher and L. C. Keil Arterial baroreceptors control blood pressure and vasopressin responses to hemorrhage in conscious dogs Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1843 - R1857. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
