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Am J Physiol Regul Integr Comp Physiol 267: R1302-R1308, 1994;
0363-6119/94 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 5 1302-R1308, Copyright © 1994 by American Physiological Society

ARTICLES

A specific role for TRH in release of diacetyl alpha-MSH in tilapia stressed by acid water

A. E. Lamers, G. Flik and S. E. Bonga
Department of Animal Physiology, Faculty of Science, University of Nijmegen, The Netherlands.

After exposure of tilapia for 7 days to low-pH water, plasma thyrotropin-releasing hormone (TRH) levels were elevated, and the melanocyte-stimulating hormone (MSH) cells in the pituitary pars intermedia had increased in size and showed enhanced synthetic and secretory activity. The MSH cells became more sensitive to TRH but not to corticotropin-releasing hormone (CRH). Stimulation by TRH (but not by CRH) of the MSH cells of tilapia exposed to low pH specifically enhanced the release of diacetyl alpha-MSH, the most potent corticotropic form of alpha-MSH. Acute stress imposed by handling and confinement for 1 h elevated the plasma cortisol level but did not affect blood plasma alpha-MSH levels. We conclude that stimulation by TRH is pivotal for an enhanced release of diacetyl alpha-MSH during low-pH adaptation. These results are further evidence of a role for TRH and alpha-MSH in the activation of the hypothalamopituitary-interrenal axis during adaptation to low pH.


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J. R. Metz, E. J. W. Geven, E. H. van den Burg, and G. Flik
ACTH, {alpha}-MSH, and control of cortisol release: cloning, sequencing, and functional expression of the melanocortin-2 and melanocortin-5 receptor in Cyprinus carpio
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R814 - R826.
[Abstract] [Full Text] [PDF]


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