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Am J Physiol Regul Integr Comp Physiol 268: R156-R163, 1995;
0363-6119/95 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 268, Issue 1 156-R163, Copyright © 1995 by American Physiological Society

ARTICLES

Hemodynamic response to vasopressin during V1-receptor antagonism in baroreflex-deficient subjects

K. M. Huch, K. R. Runyan, B. M. Wall, H. Gavras and C. R. Cooke
Veterans Affairs Medical Center, Memphis, Tennessee 38104.

Six quadriplegic subjects and 6 control subjects received high-dose arginine vasopressin (AVP) infusions at rates of 500, 1,000, 2,000, and 4,000 microU.kg-1.min-1 in consecutive 10-min intervals. Six additional quadriplegic subjects received low-dose AVP infusions at rates of 50, 100, 200, 400, and 800 microU.kg-1.min-1. All subjects were studied once with and once without administration of a selective V1-receptor antagonist. During high-dose AVP infusions without V1-receptor blockade, mean arterial pressure (MAP) increased from 80 +/- 4 to 87 +/- 5 mmHg (P < 0.05) in quadriplegic subjects but was unchanged in control subjects. In the presence of V1-receptor blockade, MAP decreased from 75 +/- 4 to 58 +/- 4 mmHg (P < 0.001), and heart rate (HR) increased from 61 +/- 5 to 80 +/- 5 beats/min (P < 0.001) in quadriplegic subjects. In the studies on control subjects, MAP decreased only from 75 +/- 3 to 72 +/- 5 mmHg (P < 0.05), whereas HR increased from 64 +/- 4 to 87 +/- 4 beats/min (P < 0.001). Plasma renin activity (PRA) increased in both quadriplegic and control subjects. The effects of low-dose AVP infusions on MAP, HR, and PRA in quadriplegic subjects were similar to those observed during high-dose infusions. Thus, in the absence of baroreceptor-mediated sympathetic nervous system responses, a vasodilatory effect of AVP that is capable of producing marked reductions in MAP can be demonstrated in the presence of V1-receptor blockade.


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C. R. Cooke, B. M. Wall, K. M. Huch, and T. Mangold
Cardiovascular effects of vasopressin following V1 receptor blockade compared to effects of nitroglycerin
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R887 - R893.
[Abstract] [Full Text] [PDF]


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