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Am J Physiol Regul Integr Comp Physiol 268: R299-R302, 1995;
0363-6119/95 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 268, Issue 1 299-R302, Copyright © 1995 by American Physiological Society

ARTICLES

Whole body energy expenditure and fuel oxidation after 2,5-anhydro-D-mannitol administration

C. R. Park, R. J. Seeley, L. Benthem, M. I. Friedman and S. C. Woods
Behavioral Neuroscience Interdisciplinary Group, University of Washington, Seattle 98195.

The fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) increases food intake in nondeprived rats. Several lines of evidence indicate that vagal signals arising from the liver are critical for this effect. In addition, 2,5-AM decreases plasma glucose and increases lipolysis, resulting in an increase in plasma free fatty acids and ketone bodies. In these respects 2,5-AM produces a state analogous to that observed after food deprivation. Using an indirect calorimeter, we determined that 2,5-AM (300 mg/kg ip) causes a potent and long-lasting decrease in respiratory quotient, indicating a decrease in the fraction of total energy derived from carbohydrate oxidation and an increase in the fraction derived from fatty acid oxidation. These metabolic variables were altered without affecting total metabolic rate. This dose of analogue also stimulated significantly greater food intake than injections of vehicle. These results support the continued use of 2,5-AM as a tool to probe the metabolic controls of food intake.


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