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Am J Physiol Regul Integr Comp Physiol 268: R498-R505, 1995;
0363-6119/95 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 268, Issue 2 498-R505, Copyright © 1995 by American Physiological Society

ARTICLES

Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats

Z. Y. Chen, C. R. Menard and S. C. Cunnane
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.

In rats, the response of adipose tissue composition to a single weight cycle (24-48 h of fasting followed by refeeding) is characterized by a decrease primarily in linoleate and alpha-linolenate, with little or no change in other fatty acids. We tested the hypothesis that during successive weight cycles caused by repeated fasting and refeeding, the depletion of linoleate and alpha-linolenate from whole body stores would be exacerbated despite their adequate availability during the refeeding period. Four complete weight cycles (24-h fasting followed by 72-h ad libitum refeeding) induced a significant quantitative decrease in total n-3 and n-6 polyunsaturates, particularly linoleate and alpha-linolenate, and a simultaneous increase in the accumulation of palmitate, palmitoleate, and oleate in carcass total lipids and in perirenal and epididymal adipose tissue. A significant positive relationship was observed between the increasing ratio of saturates+monounsaturates to n-3 + n-6 polyunsaturates in adipose tissue and the number of weight cycles (r = +0.96, P < 0.0001). The percentage of linoleate and alpha-linolenate in adipose tissue was inversely related to the number of weight cycles. We conclude that, despite providing adequate n-6 and n-3 polyunsaturates in the diet during the refeeding period, weight cycling in young growing rats causes a moderate, selective depletion of linoleate and alpha-linolenate from tissue stores.


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M.-M. Sea, W. P. Fong, Y. Huang, and Z.-Y. Chen
Weight cycling-induced alteration in fatty acid metabolism
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R1145 - R1155.
[Abstract] [Full Text] [PDF]


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