| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 268, Issue 4 958-R962, Copyright © 1995 by American Physiological Society
ARTICLES |
J. Zanzinger, J. Czachurski and H. Seller
I. Physiologisches Institut, Universitat Heidelberg, Germany.
We examined possible functional roles for nitric oxide (NO) in the rostral ventrolateral medulla (RVLM), which is the final area for integration of sympathetic nerve activity (SNA) within the brain stem. Chloralose-anesthetized cats were completely baro- and chemoreceptor denervated, the RVLM was exposed for microinjections, and preganglionic SNA was recorded from the white ramus of the 3rd thoracic segment. Injections of NG-nitro-L-arginine (L-NNA), an inhibitor of NO synthase, but not of NG-nitro-D-arginine, caused distinct increases in SNA and arterial blood pressure (BP). Excitatory somatosympathetic reflex amplitudes evoked by electrical stimulation of the 4th intercostal nerve were significantly increased by L-NNA whereas inhibitory responses to baroreflex activation by stimulation of the carotid sinus nerve were not affected. The effects of L-NNA were counteracted by the NO-donor compounds glyceryltrinitrate and S-nitroso-N-acetylpenicillamine, which decreased BP and SNA below control values at higher doses. These results suggest that endogenous NO, in addition to its peripheral actions, modulates the central nervous control of cardiovascular functions by reduction of basal sympathetic tone and by attenuation of excitatory reflex responses.
This article has been cited by other articles:
|
|
 |
|
  I. H. Zucker Novel Mechanisms of Sympathetic Regulation in Chronic Heart Failure Hypertension, December 1, 2006; 48(6): 1005 - 1011. [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Augustyniak, R. G. Victor, D. A. Morgan, and W. Zhang L-NAME- and ADMA-induced sympathetic neural activation in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R726 - R732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Mayorov Selective Sensitization by Nitric Oxide of Sympathetic Baroreflex in Rostral Ventrolateral Medulla of Conscious Rabbits Hypertension, May 1, 2005; 45(5): 901 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Monahan, I. Eskurza, and D. R. Seals Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2113 - H2117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, R. Zhang, T. E. Wilson, S. Witkowski, C. G. Crandall, and B. D. Levine Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2105 - H2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, K. P. Patel, K. G. Cornish, K. M. Channon, and I. H. Zucker nNOS gene transfer to RVLM improves baroreflex function in rats with chronic heart failure Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1660 - H1667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Meyrelles, R. V. Sharma, H. Z. Mao, F. M. Abboud, and M. W. Chapleau Modulation of baroreceptor activity by gene transfer of nitric oxide synthase to carotid sinus adventitia Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1190 - R1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Cooke, R. Zhang, J. H. Zuckerman, J. Cui, T. E. Wilson, C. G. Crandall, and B. D. Levine Does nitric oxide buffer arterial blood pressure variability in humans? J Appl Physiol, October 1, 2002; 93(4): 1466 - 1470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Tjen-A-Looi, N. T. Phan, and J. C. Longhurst Nitric oxide modulates sympathoexcitatory cardiac-cardiovascular reflexes elicited by bradykinin Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2010 - H2017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Greenwood, E. M. Scott, J. B. Stoker, J. J. Walker, and D. A.S.G. Mary Sympathetic Neural Mechanisms in Normal and Hypertensive Pregnancy in Humans Circulation, October 30, 2001; 104(18): 2200 - 2204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y.H. Chan, L.-L. Wang, K. L.H. Wu, and S. H.H. Chan Reduced Functional Expression and Molecular Synthesis of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats Circulation, October 2, 2001; 104(14): 1676 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Patel, Y.-F. Li, and Y. Hirooka Role of Nitric Oxide in Central Sympathetic Outflow Experimental Biology and Medicine, October 1, 2001; 226(9): 814 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kishi, Y. Hirooka, K. Sakai, H. Shigematsu, H. Shimokawa, and A. Takeshita Overexpression of eNOS in the RVLM Causes Hypotension and Bradycardia Via GABA Release Hypertension, October 1, 2001; 38(4): 896 - 901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakai, Y. Hirooka, I. Matsuo, K. Eshima, H. Shigematsu, H. Shimokawa, and A. Takeshita Overexpression of eNOS in NTS Causes Hypotension and Bradycardia In Vivo Hypertension, December 1, 2000; 36(6): 1023 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Arnolda, D. J. McKitrick, I. J. Llewellyn-Smith, and J. B. Minson Nitric Oxide Limits Pressor Responses to Sympathetic Activation in Rat Spinal Cord Hypertension, December 1, 2000; 36(6): 1089 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Stauss and P. B. Persson Role of Nitric Oxide in Buffering Short-Term Blood Pressure Fluctuations Physiology, October 1, 2000; 15(5): 229 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Martins-Pinge, G. C. Araujo, and O. U. Lopes Nitric Oxide-Dependent Guanylyl Cyclase Participates in the Glutamatergic Neurotransmission Within the Rostral Ventrolateral Medulla of Awake Rats Hypertension, October 1, 1999; 34(4): 748 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hogan, A. Kardos, D. J. Paterson, and B. Casadei Effect of exogenous nitric oxide on baroreflex function in humans Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H221 - H227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ma, I. H. Zucker, and W. Wang Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H19 - H26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kurihara, M. E. Alfie, D. H. Sigmon, N.-E. Rhaleb, E. G. Shesely, and O. A. Carretero Role of nNOS in Blood Pressure Regulation in eNOS Null Mutant Mice Hypertension, November 1, 1998; 32(5): 856 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sakima, H. Teruya, M. Yamazato, R. Matayoshi, H. Muratani, and K. Fukiyama Prolonged NOS inhibition in the brain elevates blood pressure in normotensive rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R410 - R417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zanzinger, J. Czachurski, and H. Seller Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R33 - R39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kagiyama, T. Tsuchihashi, I. Abe, and M. Fujishima Enhanced Depressor Response to Nitric Oxide in the Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats Hypertension, April 1, 1998; 31(4): 1030 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Liu, H. Murakami, and I. H. Zucker Angiotensin II–Nitric Oxide Interaction on Sympathetic Outflow in Conscious Rabbits Circ. Res., March 9, 1998; 82(4): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sander, J. Hansen, and R. G. Victor The Sympathetic Nervous System Is Involved in the Maintenance but Not Initiation of the Hypertension Induced by N{omega}-Nitro-L-Arginine Methyl Ester Hypertension, July 1, 1997; 30(1): 64 - 70. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. S. Muntzel, A. Abe, and J. S. Petersen Effects of Adrenergic, Cholinergic and Ganglionic Blockade on Acute Depressor Responses to Metformin in Spontaneously Hypertensive Rats J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 618 - 623. [Abstract] [Full Text]
|
|
|
|
|
|
J. Zanzinger, J. Czachurski, and H. Seller Neuronal Nitric Oxide Reduces Sympathetic Excitability by Modulation of Central Glutamate Effects in Pigs Circ. Res., April 19, 1997; 80(4): 565 - 571. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Petersen and G. F. DiBona Acute Sympathoinhibitory Actions of Metformin in Spontaneously Hypertensive Rats Hypertension, March 1, 1996; 27(3): 619 - 625. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
