AJP - Regulatory, Integrative and Comparative Physiology, Vol 268, Issue 5 1129-R1136, Copyright © 1995 by American Physiological Society

ARTICLES

Mechanical basis of ANP secretion in beating atria: atrial stroke volume and ECF translocation

K. W. Cho, S. H. Kim, C. H. Kim and K. H. Seul
Department of Physiology, Jeonbug National University Medical School, Republic of Korea.

To investigate the mechanism by which an increase in pacing frequency or distension increases the secretion of atrial natriuretic peptide (ANP), the changes in atrial volume during contraction (atrial stroke volume), transmural transport of the extracellular fluid (ECF), and ANP secretion were quantified in the beating perfused rabbit atria. The atrium was stimulated by transmural field stimulation or by atrial distension induced by an increase in intraatrial pressure. Atrial stretch and incremental increases in pacing frequency up to 2 Hz activated the secretion of ANP coincident with an increase in atrial stroke volume and the transendocardial translocation of the ECF. These results showed positive relationships between changes in the secretion of ANP and the atrial stroke volume or the translocation of the ECF. The translocation of the ECF was also positively correlated with the change in atrial stroke volume. The accentuated secretion of ANP and translocation of the ECF waned at higher stimulating rates to show a peak value. Even under this condition, the secretion of ANP was a function of the translocation of the ECF. These data suggest that the increases in atrial stroke volume and translocation of ECF are fundamental factors in the ANP stimulation in response to atrial stretch and increases in atrial rate.

This article has been cited by other articles:

				J. Y. Jin, J. F. Wen, D. Li, and K. W. Cho Osmoregulation of atrial myocytic ANP release: osmotransduction via cross-talk between L-type Ca2+ channel and SR Ca2+ release Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1101 - R1109. [Abstract] [Full Text] [PDF]

				D. Li, J. F. Wen, J. Y. Jin, H. Jin, H. S. Ann, S. Z. Kim, S. H. Kim, H. S. Lee, and K. W. Cho Histamine inhibits atrial myocytic ANP release via H2 receptor-cAMP-protein kinase signaling Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R380 - R393. [Abstract] [Full Text] [PDF]

				S. H. Kim, G. Y. Koh, K. W. Cho, W.-Y. Park, and J.-S. Seo Stretch-Activated Atrial Natriuretic Peptide Secretion in Atria with Heat Shock Protein 70 Overexpression Experimental Biology and Medicine, February 1, 2003; 228(2): 200 - 206. [Abstract] [Full Text] [PDF]

				X. Cui, J. F. Wen, J. Y. Jin, W. X. Xu, S. Z. Kim, S. H. Kim, H. S. Lee, and K. W. Cho Protein kinase-dependent and Ca2+-independent cAMP inhibition of ANP release in beating rabbit atria Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1477 - R1489. [Abstract] [Full Text] [PDF]

				J. F. Wen, X. Cui, J. S. Ahn, S. H. Kim, K. H. Seul, S. Z. Kim, Y. K. Park, H. S. Lee, and K. W. Cho Distinct roles for L- and T-type Ca2+ channels in regulation of atrial ANP release Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2879 - H2888. [Abstract] [Full Text] [PDF]

				S. J. Lee, S. Z. Kim, X. Cui, S. H. Kim, K. S. Lee, Y. J. Chung, and K. W. Cho C-type natriuretic peptide inhibits ANP secretion and atrial dynamics in perfused atria: NPR-B-cGMP signaling Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H208 - H221. [Abstract] [Full Text] [PDF]

				S. Z. Kim, K. W. Cho, and S. H. Kim Modulation of endocardial natriuretic peptide receptors in right ventricular hypertrophy Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2280 - H2289. [Abstract] [Full Text] [PDF]