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Am J Physiol Regul Integr Comp Physiol 268: R1513-R1519, 1995;
0363-6119/95 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 268, Issue 6 1513-R1519, Copyright © 1995 by American Physiological Society

ARTICLES

Modulation of feeding by beta 2-microglobulin, a marker of immune activation

C. R. Plata-Salaman, G. Sonti and J. P. Borkoski
School of Life and Health Sciences, University of Delaware, Newark 19716, USA.

Increased levels of beta 2-microglobulin (part of the class I major histocompatibility complex molecules) in body fluids are associated with activation of the immune system and pathophysiological processes. Various anorexigenic cytokines, including interferon-gamma and tumor necrosis factor-alpha, induce the expression of class I molecules. Therefore, it is possible that beta 2-microglobulin may participate in the feeding suppression induced by cytokines or may have direct effects on feeding. In the present study, the effects of beta 2-microglobulin on the central regulation of feeding were investigated. Intracerebroventricular (ICV) microinfusion of beta 2-microglobulin (0.01-5.0 micrograms/rat) suppressed the nighttime food intake dose dependently. The most effective dose of beta 2-microglobulin, 5.0 micrograms/rat, decreased nighttime feeding by 38% and total daily food intake by 28%. Computerized analysis of behavioral patterns demonstrated that beta 2-microglobulin decreased meal size and meal frequency during the initial 4-h interval, but decreased only meal size during the second 4-h interval after the ICV microinfusion of 5.0 micrograms beta 2-microglobulin/rat; meal duration was not significantly affected in any interval. For the complete nighttime period, only meal size was significantly decreased. Cerebrospinal fluid-brain and rectal temperatures did not change significantly. ICV microinfusion of heat-treated beta 2-microglobulin or intraperitoneal administration of beta 2-microglobulin, in doses equivalent to those administered centrally, had no effect on food intake. The results suggest that beta 2-microglobulin may act centrally to decrease feeding, and this effect may participate in the anorexia frequently accompanying pathological processes.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. C. Flynn, T. R. Scott, T. C. Pritchard, and C. R. Plata-Salaman
Mode of action of OB protein (leptin) on feeding
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R174 - R179.
[Abstract] [Full Text] [PDF]


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