AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 269: R294-R299, 1995;
0363-6119/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Imeri, L.
Right arrow Articles by Mancia, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Imeri, L.
Right arrow Articles by Mancia, M.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 269, Issue 2 294-R299, Copyright © 1995 by American Physiological Society

ARTICLES

Stimulation of cholinergic receptors in the medial preoptic area affects sleep and cortical temperature

L. Imeri, S. Bianchi, P. Angeli and M. Mancia
Istituto di Fisiologia Umana II, Universita degli Studi, Milan, Italy.

The medial preoptic area (MPA), a cholinoceptive brain area devoid of cholinergic cells, plays an important role in the regulation of different physiological functions, particularly sleep control and thermoregulation. To investigate the effects of the stimulation of cholinergic receptors in this area on sleep and cortical temperature (Tcort), carbachol (a mixed cholinergic agonist) was directly microinjected into the MPA of freely moving rats. Carbachol (0.25 and 0.5 microgram, corresponding to 1.37 and 2.74 nmol) microinjection induced an increase in wakefulness and an inhibition of both slow wave and desynchronized sleep phases. The temperature of the cerebral cortex was reduced in comparison with control conditions (saline microinjection). Sterile needle insertion and saline microinjections induced a significant increase in Tcort, but no changes in the sleep-wake cycle compared with the handling of the animal. The results suggest that 1) carbachol microinjection into the MPA can activate an arousal-generating system and affect thermoregulatory mechanisms, and 2) sleep and temperature responses may be dissociated.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. M. Brudzynski, L. Kadishevitz, and X.-W. Fu
Mesolimbic Component of the Ascending Cholinergic Pathways: Electrophysiological-Pharmacological Study
J Neurophysiol, April 1, 1998; 79(4): 1675 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Imeri, S. Bianchi, and M. Mancia
Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1663 - R1668.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online