AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 270: R283-R288, 1996;
0363-6119/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scarbrough, K.
Right arrow Articles by Wise, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scarbrough, K.
Right arrow Articles by Wise, P. M.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 270, Issue 1 283-R288, Copyright © 1996 by American Physiological Society

ARTICLES

Acute effects of antisense antagonism of a single peptide neurotransmitter in the circadian clock

K. Scarbrough, J. P. Harney, K. L. Rosewell and P. M. Wise
Department of Physiology, University of Kentucky College of Medicine, Lexington 40536, USA. kscarbro@casbah.ancs.nwu.edu

The circadian clock that resides in the suprachiasmatic nucleus (SCN) of the hypothalamus is the major neural pacemaker driving most 24-h rhythms in mammals. Several neurotransmitter peptides are synthesized within this nucleus and communicate rhythmically with other cells in the SCN as well as with cells in other regions of the brain. At the present time, little is known about their role in regulating outputs of the clock. We demonstrate that antisense oligodeoxynucleotides corresponding to the NH2-terminus and the translation start site of vasoactive intestinal peptide (VIP) mRNA infused into the suprachiasmatic region of rats temporarily abolishes the circadian rhythm of corticosterone secretion without influencing stress-related corticosterone secretion in the same animals. Levels of VIP peptide are suppressed 30% on the second day after antisense treatment. These results indicate that a single neuropeptide transmitter in the circadian clock may serve a distinct role in the control of specific circadian rhythms.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Shen, C. Spratt, W. J. Sheward, I. Kallo, K. West, C. F. Morrison, C. W. Coen, H. M. Marston, and A. J. Harmar
Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice
PNAS, October 10, 2000; 97(21): 11575 - 11580.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Poncet, J.-M. Pequignot, J.-M. Cottet-Emard, Y. Dalmaz, and L. Denoroy
Altered daily rhythms of brain and pituitary indolamines and neuropeptides in long-term hypoxic rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R66 - R75.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Krajnak, M. L. Kashon, K. L. Rosewell, and P. M. Wise
Aging Alters the Rhythmic Expression of Vasoactive Intestinal Polypeptide mRNA But Not Arginine Vasopressin mRNA in the Suprachiasmatic Nuclei of Female Rats
J. Neurosci., June 15, 1998; 18(12): 4767 - 4774.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online