AJP - Regulatory, Integrative and Comparative Physiology, Vol 270, Issue 2 479-R485, Copyright © 1996 by American Physiological Society

ARTICLES

Activation of sympathetic outflow by recombinant human interleukin-1 beta in conscious rats

H. Kannan, Y. Tanaka, T. Kunitake, Y. Ueta, Y. Hayashida and H. Yamashita
Department of Physiology, Miyazaki Medical College, Japan.

The present study was undertaken to determine the effects of interleukin-1 beta (IL-1 beta) on renal sympathetic nerve activity (RSNA), arterial blood pressure (AP), heart rate (HR), and body temperature in conscious rats. Either intravenous or intracerebroventricular administration of IL-1 beta elicited increases in AP, HR, and RSNA accompanied by a rise in body temperature. The maximum changes in AP, HR, and RSNA occurred 10-15 min after intravenous injection of IL-1 beta (100 ng) and 20-25 min after intracerebroventricular injection (5 ng). The responses induced by the intravenous and intracerebroventricular injections lasted for approximately 15-30 min and did not appear when the animals were pretreated with the cyclooxygenase inhibitor indomethacin (10 mg/kg iv). Moreover, intracerebroventricular injection of prostaglandin E2 (1 microgram) produced responses similar to those induced by IL-1 but with shorter latency. Plasma norepinephrine and adrenocorticotropic hormone concentrations were increased after IL-1 beta injection. The results suggested that IL-1 beta augments cardiovascular and sympathetic outflow through the central action of prostaglandin E2 in conscious rats.

This article has been cited by other articles:

				N. Lu, Y. Wang, F. Blecha, R. J. Fels, H. P. Hoch, and M. J. Kenney Central interleukin-1beta antibody increases renal and splenic sympathetic nerve discharge Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1536 - H1541. [Abstract] [Full Text] [PDF]

				M. J. Kenney, F. Blecha, Y. Wang, R. McMurphy, and R. J. Fels Sympathoexcitation to intravenous interleukin-1beta is dependent on forebrain neural circuits Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H501 - H505. [Abstract] [Full Text] [PDF]

				M. J. Kenney, F. Blecha, R. J. Fels, and D. A. Morgan Altered frequency responses of sympathetic nerve discharge bursts after IL-1beta and mild hypothermia J Appl Physiol, July 1, 2002; 93(1): 280 - 288. [Abstract] [Full Text] [PDF]

				M. J. Kenney, F. Blecha, D. A. Morgan, and R. J. Fels Interleukin-1beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2441 - H2445. [Abstract] [Full Text] [PDF]

				T. Watanabe, Y. Sakata, T. Fujioka, D. Sadamitsu, and T. Maekawa Glucocorticoid Enhances Interleukin-1-Induced Pressor Response in Freely Moving Rats Through Its Effect on Nitric Oxide Release J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 24 - 30. [Abstract] [Full Text]

				M. H. Porter, B. J. Hrupka, W. Langhans, and G. J. Schwartz Vagal and splanchnic afferents are not necessary for the anorexia produced by peripheral IL-1beta , LPS, and MDP Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R384 - R389. [Abstract] [Full Text] [PDF]