AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 271: R634-R640, 1996;
0363-6119/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gingalewski, C.
Right arrow Articles by De Maio, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gingalewski, C.
Right arrow Articles by De Maio, A.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 3 634-R640, Copyright © 1996 by American Physiological Society

ARTICLES

Distinct expression of heat shock and acute phase genes during regional hepatic ischemia-reperfusion

C. Gingalewski, N. G. Theodorakis, J. Yang, S. C. Beck and A. De Maio
Johns Hopkins University School of Medicine, Baltimore, Maryland 21187, USA.

The hepatic response to injury is orchestrated by the expression of different gene groups (i.e., heat shock and acute phase). In the present study, the expression of heat shock and acute phase genes was analyzed in the context of a localized injury, regional hepatic ischemia-reperfusion. Left and median liver lobes were subjected to 1 h of ischemia, whereas blood flow was maintained to the remainder of the organ. After the period of ischemia, the organ was reperfused, and samples of the ischemic and nonischemic liver were obtained at different time points during reperfusion. Expression of the heat shock gene, HSP 72, was detected only in the ischemic liver, whereas expression of the acute phase gene, beta-fibrinogen, and the interleukin-6-inducible gene, metallothionein, was maximally induced in the nonischemic liver and attenuated in the ischemic liver. To determine how the heat shock and acute phase responses were reprioritized during stress, expression of beta-fibronogen and HSP 72 was induced simultaneously in the same animal by administration of endotoxin and total body hyperthermia, respectively. Administration of endotoxin did not impede the expression of HSP 72; however, heat shock attenuated, but did not eliminate, the endotoxin-induced expression of beta-fibronogen. These observations suggest that the heat shock and acute phase responses are not mutually exclusive.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. J. Wigmore, K. C. H. Fearon, J. A. Ross, S. J. McNally, W. J. Welch, and O. J. Garden
Febrile-range temperature but not heat shock augments the acute phase response to interleukin-6 in human hepatoma cells
Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G903 - G911.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. A. Sonna, J. Fujita, S. L. Gaffin, and C. M. Lilly
Molecular Biology of Thermoregulation: Invited Review: Effects of heat and cold stress on mammalian gene expression
J Appl Physiol, April 1, 2002; 92(4): 1725 - 1742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. G. Theodorakis and A. de Maio
Cx32 mRNA in rat liver: effects of inflammation on poly(A) tail distribution and mRNA degradation
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1249 - R1257.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online