AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 271: R1193-R1198, 1996;
0363-6119/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Redl, H.
Right arrow Articles by Foulkes, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Redl, H.
Right arrow Articles by Foulkes, R.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 5 1193-R1198, Copyright © 1996 by American Physiological Society

ARTICLES

Endogenous modulators of TNF and IL-1 response are under partial control of TNF in baboon bacteremia

H. Redl, G. Schlag, E. Paul, S. Bahrami, W. A. Buurman, R. M. Strieter, S. L. Kunkel, J. Davies and R. Foulkes
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.

Tumor necrosis factor (TNF) and interleukin (IL)-1 are two cytokines for which naturally occurring inhibitors have been identified. The present study was undertaken to evaluate the extent to which scavenging of TNF in bacteremia attenuates the plasma levels of IL-1 receptor antagonist (IL-1ra) and soluble TNF receptors (sTNFR). Ten male baboons received 2 x 10(9) colony-forming units/kg live Escherichia coli over 2 h and were subjected to either placebo or anti-TNF antibody (anti-TNF Ab) treatment (1 mg/kg CDP571, Celltech, UK) 2 h before E. coli infusion (observation time: 72h). IL-1ra (range: 50-100 ng/ml) and sTNFR (range: 55kDa, 20-25 ng/ml; 75 kDa, 30-35 ng/ml) release was more sustained than that of IL-1 and TNF and was significantly attenuated by anti-TNF treatment, as were the circulating levels of IL-1, IL-8, and monocyte chemotactic peptide-1 (MCP-1) in the anti-TNF Ab group. We conclude that the increase in circulating natural cytokine modulators observed in nonhuman primate bacteremia is under the partial control of endogenous TNF because it was influenced by anti-TNF pretreatment. This attenuation is comparable to the anti-TNF effect on the chemokine MCP-1.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
K. Doerschug, S. Sanlioglu, D. M. Flaherty, R. L. Wilson, T. Yarovinsky, M. M. Monick, J. F. Engelhardt, and G. W. Hunninghake
First-Generation Adenovirus Vectors Shorten Survival Time in a Murine Model of Sepsis
J. Immunol., December 1, 2002; 169(11): 6539 - 6545.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. E. P. Dekkers, M. Levi, S. J. H. van Deventer, and T. van der Poll
Divergent Roles of Tumor Necrosis Factor and Platelet-Activating Factor in Endotoxin-Induced Release of Monocyte Chemoattractant Protein 1 and Macrophage Inflammatory Protein 1beta in Chimpanzees
Infect. Immun., October 1, 1999; 67(10): 5480 - 5482.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online