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Am J Physiol Regul Integr Comp Physiol 271: R1594-R1601, 1996;
0363-6119/96 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 6 1594-R1601, Copyright © 1996 by American Physiological Society

ARTICLES

Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults

B. S. Stonestreet, C. S. Patlak, K. D. Pettigrew, C. B. Reilly and H. F. Cserr
Department of Pediatrics, Brown University School of Medicine, Providence, Rhode Island, USA.

The ontogeny of regional blood-brain barrier function was quantified with the rate constant for influx (Ki) across the blood-brain barrier with the small molecular weight synthetic, inert hydrophilic amino acid alpha-aminoisobutyric acid (AIB) in chronically instrumented early (87 days of gestation, 60% of gestation) and late (137 days of gestation, 90% of gestation) gestation fetal, newborn (3 days of age), older (24 days of age), and adult (3 years of age) sheep. The Ki was significantly (P < 0.05) lower in the brain regions of the adult sheep and in most brain regions of newborn and older lambs compared with fetuses at 60 and 90% of gestation. The Ki exhibited regional brain heterogeneity (P < 0.05) in the five groups. The patterns of regional heterogeneity were accentuated (P < 0.05) in the younger groups. We conclude that ontogenic decreases in blood-brain barrier permeability are observed in ovine fetuses from 60% of gestation to maturity in the adult.


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