| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 6 1770-R1774, Copyright © 1996 by American Physiological Society
ARTICLES |
O. Stehling, H. Doring, J. Ertl, G. Preibisch and I. Schmidt
Max-Planck-Institut fur physiologische und klinische Forschung, W. G. Kerckhoff-Institut, Bad Nauheim, Germany.
The recently identified hormone leptin (ob protein) secreted by white adipose tissue is widely thought to provide a feedback signal limiting fat storage by decreasing food intake. By artificially rearing leptin-treated and control littermates fed identical amounts of milk, however, we show here that lean suckling-age rats treated with recombinant murine leptin can reduce fat storage solely by increasing energy expenditure. Continuous measurements of core temperature and metabolic rate show that this increase is not uniform throughout the day but is especially prominent in the morning when rat pups usually conserve energy by entering a torpor-like state. Leptin's alleviation of hypometabolic, torpor-like states is thus not restricted to cases of impaired hormone production but seems instead to be a normal biological function independent of its effects on food intake.
This article has been cited by other articles:
|
|
 |
|
  K. M. Pelz, D. Routman, J. R. Driscoll, L. J. Kriegsfeld, and J. Dark Monosodium glutamate-induced arcuate nucleus damage affects both natural torpor and 2DG-induced torpor-like hypothermia in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R255 - R265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Levin Neurotrophism and energy homeostasis: perfect together Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R988 - R991. [Full Text] [PDF]
|
|
|
|
|
|
J. A. DiMicco and D. V. Zaretsky The dorsomedial hypothalamus: a new player in thermoregulation Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R47 - R63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Varma, J. He, B.-C. Shin, L. A. Weissfeld, and S. U. Devaskar Postnatal intracerebroventricular exposure to leptin causes an altered adult female phenotype Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1132 - E1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Nelson Leptin: the "skinny" on torpor Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R6 - R7. [Full Text] [PDF]
|
|
|
|
|
|
D. A. Freeman, D. A. Lewis, A. S. Kauffman, R. M. Blum, and J. Dark Reduced leptin concentrations are permissive for display of torpor in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R97 - R103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Dobbins, L. S. Szczepaniak, W. Zhang, and J. D. McGarry Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E778 - E787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bowen, T. D. Mitchell, and R. B. S. Harris Method of leptin dosing, strain, and group housing influence leptin sensitivity in high-fat-fed weanling mice Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R87 - R100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schoelch, T. Hubschle, I. Schmidt, and B. Nuesslein-Hildesheim MSG lesions decrease body mass of suckling-age rats by attenuating circadian decreases of energy expenditure Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E604 - E611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Reidy and J.-M. Weber Accelerated substrate cycling: a new energy-wasting role for leptin in vivo Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E312 - E317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. ZHANG, C. HUFNAGEL, S. EIDEN, K.-Y. GUO, P. A. DIAZ, R. L. LEIBEL, and I. SCHMIDT Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups Physiol Genomics, January 19, 2001; 4(3): 189 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Truett, J. A. Walker, and R. B. S. Harris A developmental switch affecting growth of fatty rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R1956 - R1963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. SCHMIDT, C. SCHOELCH, T. ZISKA, D. SCHNEIDER, E. SIMON, and A. PLAGEMANN Interaction of genetic and environmental programming of the leptin system and of obesity disposition Physiol Genomics, August 9, 2000; 3(2): 113 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Z. Zhao, M. M. Shinohara, D. Huang, M. Shimizu, H. Eldar-Finkelman, E. G. Krebs, J. A. Beavo, and K. E. Bornfeldt Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes J. Biol. Chem., April 6, 2000; 275(15): 11348 - 11354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rafael and A. W. Herling Leptin effect in ob/ob mice under thermoneutral conditions depends not necessarily on central satiation Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R790 - R795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Gavrilova, L. R. Leon, B. Marcus-Samuels, M. M. Mason, A. L. Castle, S. Refetoff, C. Vinson, and M. L. Reitman Torpor in mice is induced by both leptin-dependent and -independent mechanisms PNAS, December 7, 1999; 96(25): 14623 - 14628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Mistry, A. Swick, and D. R. Romsos Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R742 - R747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kraeft, K. Schwarzer, S. Eiden, B. Nuesslein-Hildesheim, G. Preibisch, and I. Schmidt Leptin responsiveness and gene dosage for leptin receptor mutation (fa) in newborn rats Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E836 - E842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Blumberg, K. Deaver, and R. F. Kirby Leptin disinhibits nonshivering thermogenesis in infants after maternal separation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R606 - R610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Geiser, G. Kortner, and I. Schmidt Leptin increases energy expenditure of a marsupial by inhibition of daily torpor Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1627 - R1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kahler, N. Geary, L. A. Eckel, L. A. Campfield, F. J. Smith, and W. Langhans Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R180 - R185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Klaus, H. Munzberg, C. Truloff, and G. Heldmaier Physiology of transgenic mice with brown fat ablation: obesity is due to lowered body temperature Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R287 - R293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Muller, J. Ertl, M. Gerl, and G. Preibisch Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes J. Biol. Chem., April 18, 1997; 272(16): 10585 - 10593. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
