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Am J Physiol Regul Integr Comp Physiol 272: R482-R486, 1997;
0363-6119/97 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 2 482-R486, Copyright © 1997 by American Physiological Society

ARTICLES

Contemporaneous melatonin administration modifies the circadian response to nocturnal bright light stimuli

A. Cagnacci, R. Soldani and S. S. Yen
Department of Reproductive Medicine, University of California San Diego, La Jolla 92093-0633, USA.

We investigated whether the contemporaneous administration of melatonin can modify circadian phase shifts induced by bright light stimuli. After a baseline evaluation, 10 women were exposed for three consecutive nights to a 4-h bright light stimulus (>3,000 lx) initiated at the time of the estimated core body temperature (BT(c)) nadir. Along with light, each woman orally received, randomly and in a double-blind fashion, placebo (n = 5) or melatonin (n = 5; 1 mg 30 min before and 0.75 mg 120 min after the start of light exposure). Daily rhythms were reevaluated at the end of treatment. Bright light phase advanced, by about 90-120 min, BT(c) (P < 0.01), cortisol (P < 0.05), and melatonin (P < 0.01) rhythms. Contemporaneous administration of melatonin antagonized the phase advances of the cortisol and BT(c) rhythms, as well as the melatonin peak and melatonin offset. The phase advance of the melatonin onset was instead enhanced (P < 0.05). Contemporaneous melatonin administration modifies the capability of light to induce circadian phase shifts.


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Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1369 - R1380.
[Abstract] [Full Text] [PDF]


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