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Am J Physiol Regul Integr Comp Physiol 272: R1020-R1027, 1997;
0363-6119/97 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 4 1020-R1027, Copyright © 1997 by American Physiological Society

ARTICLES

Central 5-HT1A modulation of cardiovascular responses to tibial nerve stimulation-evoked muscle contraction

A. Ally, D. Caringi, D. M. Koester, T. Kobayashi and D. J. Mokler
Department of Pharmacology, University of New England College of Osteopathic Medicine, Biddeford, Maine 04005, USA.

The effects of administering 8-hydroxy-2-(di-n-propylamine) tetralin [8-OH-DPAT, a serotonin 1A (5-HT1A) receptor agonist] into the rostral ventrolateral medulla (RVLM) on cardiovascular responses during tibial nerve stimulation-evoked muscle contraction were investigated using anesthetized rats. Stimulation of the tibial nerve (3 times motor threshold, 0.1 ms, 40 Hz) for 30 s increased mean arterial pressure (MAP), heart rate (HR), and muscle tension by 25 +/- 3 mmHg, 24 +/- 4 beats/min, and 299 +/- 35 g, respectively. Bilateral microdialysis of 8-OH-DPAT (10 mM) for 30 min attenuated the stimulation-evoked increases in MAP (8 +/- 2 mmHg) and HR (11 +/- 5 beats/min), without a change in muscle tension (292 +/- 30 g). However, administration of 1 mM 8-OH-DPAT had no effect on the cardiovascular responses. Thirty minutes of microdialysis of 8-OH-DPAT (10 mM) into the caudal ventrolateral medulla produced no effect on cardiovascular responses during muscle contraction. Prior administration of 10 mM 1-[2-methoxyphenyl]-4-[4-(2-phthalimido)-butyl]piperazine (NAN-190), a 5-HT1A receptor antagonist, for 30 min into the RVLM blocked the attenuating effects of subsequent microdialysis of 8-OH-DPAT (10 mM). Results suggest that activation of 5-HT1A receptors within the RVLM inhibit cardiovascular responses elicited during static muscle contraction.


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 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Asmundsson, D. Caringi, D. J. Mokler, T. Kobayashi, T. Ishide, and A. Ally
Extracellular serotonin changes in VLM during muscle contraction: effects of 5-HT1A-receptor activation
Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2899 - H2909.
[Abstract] [Full Text] [PDF]


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