AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 5 1657-R1663, Copyright © 1997 by American Physiological Society

ARTICLES

Chemical lesion of visceral afferents causes transient overconsumption of unfamiliar high-fat diets in rats

M. Chavez, L. Kelly, D. A. York and H. R. Berthoud
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.

Because it is commonly assumed that the major role of visceral afferents in food intake control is to terminate meals by carrying negative-feedback signals to the brain, we hypothesized that overconsumption should occur in rats with chemically lesioned visceral afferents if they were presented with an unfamiliar diet. Adult male Sprague-Dawley (SD) rats were treated with multiple doses of capsaicin or vehicle as a control. Five weeks later, a series of 3-h feeding tests after 24-h deprivation was carried out, first with chow and then with either a solid (vegetable shortening) or liquid (Ensure) unfamiliar high-fat diet. Both groups consumed similar amounts of their powdered chow maintenance diet, but capsaicin-treated rats consumed at least 50% more of either high-fat diet than vehicle controls (P < 0.01) at the beginning of the first trial. During second and third trials with the now-familiar high-fat diet, intake was no longer significantly different between the two groups, suggesting rapid engagement of redundant control mechanisms. These results support a role of capsaicin-sensitive visceral afferents in providing negative feedback for early meal termination during the ingestion of unfamiliar diets.

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