AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 272: R1704-R1711, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tamura, K.
Right arrow Articles by Ishii, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tamura, K.
Right arrow Articles by Ishii, M.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 6 1704-R1711, Copyright © 1997 by American Physiological Society

ARTICLES

Modulation of tissue angiotensinogen gene expression in genetically obese hypertensive rats

K. Tamura, S. Umemura, T. Yamakawa, N. Nyui, K. Hibi, Y. Watanabe, T. Ishigami, M. Yabana, S. Tanaka, H. Sekihara, K. Murakami and M. Ishii
Second Department of Internal Medicine, Yokohama City University School of Medicine, Japan.

Wistar fatty rats (WFR) show obesity and obesity-related features, including hypertension. In this study, we examined the expression of angiotensinogen mRNA in a variety of tissues at different times in WFR and control Wistar lean rats (WLR). WFR were obese and hypertensive at 16 and 24 wk. Plasma renin activity and plasma angiotensinogen concentration showed age-dependent increases in WFR but decreases in WLR. Northern blot analysis showed no significant differences in the levels of hepatic and renal angiotensinogen mRNA between WFR and WLR, and the levels of fat and adrenal angiotensinogen mRNA were lower in WFR than in WLR. On the other hand, the levels of cardiac angiotensinogen mRNA at 16 and 24 wk and those of aortic angiotensinogen mRNA at 16 wk were significantly higher in WFR than in WLR. These results show that the expression of tissue angiotensinogen mRNA is regulated differently in WFR and WLR and indicate that the development of hypertension in WFR is accompanied at least temporally with increases in plasma angiotensinogen concentration as well as in cardiac and aortic angiotensinogen mRNA. Moreover, these results suggest the existence of obesity hypertension-linked and tissue-specific regulation of angiotensinogen gene expression.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Gabriely, X. M. Yang, J. A. Cases, X. H. Ma, L. Rossetti, and N. Barzilai
Hyperglycemia modulates angiotensinogen gene expression
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R795 - R802.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Engeli, R. Negrel, and A. M. Sharma
Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System
Hypertension, June 1, 2000; 35(6): 1270 - 1277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Tamura, S. Umemura, N. Nyui, K. Hibi, T. Ishigami, M. Kihara, Y. Toya, and M. Ishii
Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R1 - R9.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online