AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 272: R1998-R2003, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kirouac, G. J.
Right arrow Articles by Ciriello, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kirouac, G. J.
Right arrow Articles by Ciriello, J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 6 1998-R2003, Copyright © 1997 by American Physiological Society

ARTICLES

Cardiovascular afferent inputs to ventral tegmental area

G. J. Kirouac and J. Ciriello
Department of Physiology, University of Western Ontario, London, Canada.

Extracellular single-unit recording experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of selective activation of arterial baroreceptors and stimulation of cardiovascular depressor sites in the nucleus of the solitary tract (NTS) on the discharge rate of neurons in the ventral tegmental area (VTA). Electrical stimulation of the aortic depressor nerve (ADN), which is known to carry aortic baroreceptor afferent fibers only, excited 12 of 21 (mean onset latency 42.4 +/- 8.8 ms) and inhibited 2 of 21 (mean onset latency 42.5 +/- 6.5 ms) single units in the VTA. The discharge rate of VTA units was also altered during the reflex activation of arterial baroreceptors by the acute rise in arterial pressure (AP) to systemic injections of phenylephrine (10 micrograms/kg i.v.): 12 of 44 units were excited and 15 of 44 were inhibited. Units that responded to either ADN stimulation or the reflex activation of the baroreflex also responded to stimulation of depressor sites in the NTS. An additional 12 units that were found in barodenervated controls to be responsive to NTS stimulation were nonresponsive to selective activation of arterial baroreceptors. These data indicate that cardiovascular afferent inputs modulate the activity of neurons in the VTA and suggest that changes in systemic AP may exert an effect on the activity of neurons involved in mesolimbic and mesocortical function.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Hajnal, G. P. Smith, and R. Norgren
Oral sucrose stimulation increases accumbens dopamine in the rat
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R31 - R37.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. J. Kirouac and Q. J. Pittman
A projection from the ventral tegmental area to the periaqueductal gray involved in cardiovascular regulation
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1643 - R1650.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. J. Kirouac and Q. J. Pittman
Identification of barosensitive neurons in the mediobasal forebrain using juxtacellular labeling
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1766 - R1771.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. J. Kirouac and J. Ciriello
Cardiovascular depressor responses to stimulation of substantia nigra and ventral tegmental area
Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2549 - H2557.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online