AJP - Regu AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 272: R2004-R2008, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fanestil, D. D.
Right arrow Articles by Blakely, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fanestil, D. D.
Right arrow Articles by Blakely, P.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 6 2004-R2008, Copyright © 1997 by American Physiological Society

ARTICLES

Metabolic acid-base influences on renal thiazide receptor density

D. D. Fanestil, D. A. Vaughn and P. Blakely
Department of Medicine, University of California San Diego, La Jolla 92093-0623, USA.

The renal responses to metabolic acidosis/alkalosis involve changes in the proximal tubule, loop of Henle, and collecting ducts. We tested for acid- or base-induced changes in the distal convoluted tubule (DCT) by examining the renal density of the DCT's receptor for thiazide-type diuretics (TZR), as estimated by the binding of [3H]metolazone in Wistar-Kyoto rats. TZR density significantly decreased by 17% in rats ingesting NH4Cl for 3.5 days and by nearly 30% after 7 days; TZR increased up to 40% in rats ingesting NaHCO3 for 2-4 days but was no longer significantly increased after 7 days. Urinary excretion of chloride increased as renal density of the TZR decreased, a finding consistent with the interpretation that acidosis/alkalosis not only altered TZR density but coordinately altered reabsorption of NaCl by the thiazidesensitive Na-Cl cotransporter. The result is that delivery of Na from DCT is enhanced during acidosis and decreased during alkalosis, assisting in compensatory changes in distal nephron secretion of hydrogen ion. The integrated renal response to metabolic acidosis/alkalosis involves a decrease in renal TZR with acidosis and an increase in TZR with alkalosis.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
G. Gamba
Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters
Physiol Rev, April 1, 2005; 85(2): 423 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Monroy, C. Plata, S. C. Hebert, and G. Gamba
Characterization of the thiazide-sensitive Na+-Cl- cotransporter: a new model for ions and diuretics interaction
Am J Physiol Renal Physiol, July 1, 2000; 279(1): F161 - F169.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. F. Reilly and D. H. Ellison
Mammalian Distal Tubule: Physiology, Pathophysiology, and Molecular Anatomy
Physiol Rev, January 1, 2000; 80(1): 277 - 313.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. D. FANESTIL, R. H. HYDE, P. BLAKELY, and D. A. VAUGHN
Dietary Magnesium, Not Calcium, Regulates Renal Thiazide Receptor
J. Am. Soc. Nephrol., March 1, 1999; 10(3): 458 - 463.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online