AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 273: R107-R112, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gillard, E. R.
Right arrow Articles by Stanley, B. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gillard, E. R.
Right arrow Articles by Stanley, B. G.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 1 107-R112, Copyright © 1997 by American Physiological Society

ARTICLES

Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus

E. R. Gillard, A. M. Khan, , R. S. Grewal, B. Mouradi and B. G. Stanley
Department of Neuroscience, University of California at Riverside 92521, USA.

Despite intense study of neurotransmitters mediating hypothalamic controls of food intake, little is known about which second messengers are critical for these mechanisms. To determine whether adenosine 3',5'-cyclic monophosphate (cAMP) might participate in these mechanisms, we injected the membrane-permeant cAMP analog 8-bromo-cAMP (8-BrcAMP) hypothalamically in satiated rats. Injection of 8-BrcAMP (10-100 nmol) into the perifornical (PFH) and lateral hypothalamus (LH) dose dependently stimulated food intake of up to 15.7 g in 2 h. Significantly smaller responses were obtained with thalamic injections. In contrast to the strong stimulatory effects of PFH and LH 8-BrcAMP, cAMP and 8-bromo-guanosine 3',5'-cyclic monophosphate (100 nmol) were ineffective, suggesting a chemically specific, intracellular action. Consistent with this, combined PFH injection of 7-deacetyl-7-O-(N-methylpiperazino)-tau-butyryl-forskolin dihydrochloride and 3-isobutyl-1-methylxanthine, agents that increase endogeneous cAMP, stimulated eating of up to 9.9 g in 2 h. These results demonstrate that increases in PFH/LH cAMP can elicit complex, goal-oriented behavior, suggesting an important role for cAMP in hypothalamic mechanisms stimulating food intake.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Khan, M. C. Curras, J. Dao, F. A. Jamal, C. A. Turkowski, R. K. Goel, E. R. Gillard, S. D. Wolfsohn, and B. G. Stanley
Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating: immunochemical/behavioral evidence
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R880 - R891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. R. Gillard, A. M. Khan, B. Mouradi, O. Nalamwar, and B. G. Stanley
Eating induced by perifornical cAMP is behaviorally selective and involves protein kinase activity
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R647 - R653.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. R. Gillard, A. M. Khan, R. S. Grewal, B. Mouradi, S. D. Wolfsohn, and B. G. Stanley
The Second Messenger cAMP Elicits Eating by an Anatomically Specific Action in the Perifornical Hypothalamus
J. Neurosci., April 1, 1998; 18(7): 2646 - 2652.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online