AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 273: R113-R120, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahren, B.
Right arrow Articles by Havel, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahren, B.
Right arrow Articles by Havel, P. J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 1 113-R120, Copyright © 1997 by American Physiological Society

ARTICLES

Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting

B. Ahren, S. Mansson, R. L. Gingerich and P. J. Havel
Department of Medicine, Lund University, Malmo, Sweden.

Mechanisms regulating circulating leptin are incompletely understood. We developed a radioimmunoassay for mouse leptin to examine the influence of age, dietary fat content, and fasting on plasma concentrations of leptin in the background strain for the ob/ob mouse, the C57BL/6J mouse. Plasma leptin increased with age [5.3 +/- 0.6 ng/ml at 2 mo (n = 23) vs. 14.2 +/- 1.6 ng/ml at 11 mo (n = 15), P < 0.001]. Across all age groups (2-11 mo, n = 160), log plasma leptin correlated with body weight (r = 0.68, P < 0.0001), plasma insulin (r = 0.38, P < 0.001), and amount of intra-abdominal fat (r = 0.90, P < 0.001), as revealed by magnetic resonance imaging. Plasma leptin was increased by a high-fat diet (58% fat for 10 mo) and reduced by fasting for 48 h. The reduction of plasma leptin was correlated with the reduction of plasma insulin (r = 0.43, P = 0.012) but not with the initial body weight or the change in body weight. Moreover, the reduction in plasma leptin by fasting was impaired by high-fat diet. Thus plasma leptin in C57BL/6J mice 1) increases with age or a high-fat diet; 2) correlates with body weight, fat content, and plasma insulin; and 3) is reduced during fasting by an action inhibited by high-fat diet and related to changes of plasma insulin.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. E. Mitchell, R. Nogueiras, A. Morris, S. Tovar, C. Grant, M. Cruickshank, D. V. Rayner, C. Dieguez, and L. M. Williams
Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
J. Physiol., July 15, 2009; 587(14): 3573 - 3585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Bryzgalova, L. Lundholm, N. Portwood, J.-A. Gustafsson, A. Khan, S. Efendic, and K. Dahlman-Wright
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E904 - E912.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Jurczak, A. M. Danos, V. R. Rehrmann, M. B. Allison, C. C. Greenberg, and M. J. Brady
Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E952 - E963.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. Johnston, T. A. Theman, R. D. Terry, E. S. Williams, and S. A. Shore
Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administration
J Appl Physiol, January 1, 2007; 102(1): 149 - 156.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. C. Woods, S. C. Benoit, and D. J. Clegg
The Brain-Gut-Islet Connection
Diabetes, December 1, 2006; 55(Supplement_2): S114 - S121.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. S. Rossi, Y. B. Lombardo, J.-M. Lacorte, A. G. Chicco, C. Rouault, G. Slama, and S. W. Rizkalla
Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R486 - R494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Perez-Matute, A. Marti, J. A. Martinez, M. P. Fernandez-Otero, K. L. Stanhope, P. J. Havel, and M. J. Moreno-Aliaga
Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1682 - R1688.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. D. Strader, T. P. Vahl, R. J. Jandacek, S. C. Woods, D. A. D'Alessio, and R. J. Seeley
Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E447 - E453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. C. Woods
Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake
Am J Physiol Gastrointest Liver Physiol, January 1, 2004; 286(1): G7 - G13.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg, A. C. Smith, S. Wormald, P. Malenfant, C. Collier, and D. J. Dyck
Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle
Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E57 - E63.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
D. Komninou, A. Ayonote, J. P. Richie Jr., and B. Rigas
Insulin Resistance and Its Contribution to Colon Carcinogenesis
Experimental Biology and Medicine, April 1, 2003; 228(4): 396 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Swart, J. W. Jahng, J. M. Overton, and T. A. Houpt
Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1020 - R1026.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. K. Roberts, J. J. Berger, and R. J. Barnard
Long-term effects of diet on leptin, energy intake, and activity in a model of diet-induced obesity
J Appl Physiol, September 1, 2002; 93(3): 887 - 893.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. Peyron-Caso, M. Taverna, M. Guerre-Millo, A. Veronese, N. Pacher, G. Slama, and S. W. Rizkalla
Dietary (n-3) Polyunsaturated Fatty Acids Up-Regulate Plasma Leptin in Insulin-Resistant Rats
J. Nutr., August 1, 2002; 132(8): 2235 - 2240.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
X. H. Ma, R. Muzumdar, X. M. Yang, I. Gabriely, R. Berger, and N. Barzilai
Aging Is Associated With Resistance to Effects of Leptin on Fat Distribution and Insulin Action
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2002; 57(6): B225 - 231.
[Abstract] [Full Text]

Home page
 DiabetesHome page
I. Gabriely, X. H. Ma, X. M. Yang, L. Rossetti, and N. Barzilai
Leptin Resistance During Aging Is Independent of Fat Mass
Diabetes, April 1, 2002; 51(4): 1016 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Iossa, M. P. Mollica, L. Lionetti, R. Crescenzo, M. Botta, A. Barletta, and G. Liverini
Acetyl-L-Carnitine Supplementation Differently Influences Nutrient Partitioning, Serum Leptin Concentration and Skeletal Muscle Mitochondrial Respiration in Young and Old Rats
J. Nutr., April 1, 2002; 132(4): 636 - 642.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. K. Reimer and B. Ahren
Altered {beta}-Cell Distribution of pdx-1 and GLUT-2 After a Short-Term Challenge With a High-Fat Diet in C57BL/6J Mice
Diabetes, February 1, 2002; 51(90001): S138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
P. J. Havel
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. S. Herrmann, M. L. Bean, T. M. Black, P. Wang, and R. A. Coleman
High Glycemic Index Carbohydrate Diet Alters the Diurnal Rhythm of Leptin But Not Insulin Concentrations
Experimental Biology and Medicine, December 1, 2001; 226(11): 1037 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
N. Barzilai and I. Gabriely
The Role of Fat Depletion in the Biological Benefits of Caloric Restriction
J. Nutr., March 1, 2001; 131(3): 903S - 906.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
M. Shimizu-Albergine, D. L. Ippolito, and J. A. Beavo
Downregulation of Fasting-Induced cAMP Response Element-Mediated Gene Induction by Leptin in Neuropeptide Y Neurons of the Arcuate Nucleus
J. Neurosci., February 15, 2001; 21(4): 1238 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Lin, R. Martin, A. O. Schaffhauser, and D. A. York
Acute changes in the response to peripheral leptin with alteration in the diet composition
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R504 - R509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg and D. J. Dyck
Development of leptin resistance in rat soleus muscle in response to high-fat diets
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1374 - E1382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Ziotopoulou, C. S. Mantzoros, S. M. Hileman, and J. S. Flier
Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice
Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E838 - E845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
B. Lonnerdal and P. J Havel
Serum leptin concentrations in infants: effects of diet, sex, and adiposity
Am. J. Clinical Nutrition, August 1, 2000; 72(2): 484 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. L. Drazen, L. J. Kriegsfeld, J. E. Schneider, and R. J. Nelson
Leptin, but not immune function, is linked to reproductive responsiveness to photoperiod
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1401 - R1407.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
M. S. Buchowski, L. A. Simmons, K. Y. Chen, P. J. Flakoll, B. G. Mellen, and E. A. Turner
Plasma Leptin Association with Body Composition and Energy Expenditure in Sickle Cell Disease
J. Am. Coll. Nutr., April 1, 2000; 19(2): 228 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Schneider, R. M. Blum, and G. N. Wade
Metabolic control of food intake and estrous cycles in Syrian hamsters. I. Plasma insulin and leptin
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R476 - R485.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
N. Hongu and D. S. Sachan
Caffeine, Carnitine and Choline Supplementation of Rats Decreases Body Fat and Serum Leptin Concentration as Does Exercise
J. Nutr., January 1, 2000; 130(2): 152 - 157.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
I. Murray, A. D. Sniderman, P. J. Havel, and K. Cianflone
Acylation Stimulating Protein (ASP) Deficiency Alters Postprandial and Adipose Tissue Metabolism in Male Mice
J. Biol. Chem., December 17, 1999; 274(51): 36219 - 36225.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Ahren and P. J. Havel
Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells)
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R959 - R966.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
B. E Wisse, L A. Campfield, E. B Marliss, J. A Morais, R. Tenenbaum, and R. Gougeon
Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women
Am. J. Clinical Nutrition, September 1, 1999; 70(3): 321 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Ahren, P. Sauerberg, and C. Thomsen
Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice
Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E93 - E102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bryson, J. L. Phuyal, D. R. Proctor, S. C. Blair, I. D. Caterson, and G. J. Cooney
Plasma insulin rise precedes rise in ob mRNA expression and plasma leptin in gold thioglucose-obese mice
Am J Physiol Endocrinol Metab, February 1, 1999; 276(2): E358 - E364.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. S. Blumberg, K. Deaver, and R. F. Kirby
Leptin disinhibits nonshivering thermogenesis in infants after maternal separation
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R606 - R610.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. G. Tankersley, C. O'Donnell, M. J. Daood, J. F. Watchko, W. Mitzner, A. Schwartz, and P. Smith
Leptin attenuates respiratory complications associated with the obese phenotype
J Appl Physiol, December 1, 1998; 85(6): 2261 - 2269.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Lin and D. A. York
Chronic ingestion of dietary fat is a prerequisite for inhibition of feeding by enterostatin
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R619 - R623.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. A. Horwitz, J. S. Hamilton, V. H. Routh, K. Green, P. Havel, and A. Chan
Adiposity and serum leptin increase in fatty (fa/fa) BNZ neonates without decreased VMH serotonergic activity
Am J Physiol Endocrinol Metab, June 1, 1998; 274(6): E1009 - E1017.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. J. Havel, J. Y. Uriu-Hare, T. Liu, K. L. Stanhope, J. S. Stern, C. L. Keen, and B. Ahren
Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1482 - R1491.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Landt, R. L. Gingerich, P. J. Havel, W. M. Mueller, B. Schoner, J. E. Hale, and M. L. Heiman
Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans
Clin. Chem., March 1, 1998; 44(3): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Parhami, Y. Tintut, A. Ballard, A. M. Fogelman, and L. L. Demer
Leptin Enhances the Calcification of Vascular Cells : Artery Wall as a Target of Leptin
Circ. Res., May 11, 2001; 88(9): 954 - 960.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online