AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 2 677-R682, Copyright © 1997 by American Physiological Society

ARTICLES

Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits

S. Takahashi, J. Fang, L. Kapas, Y. Wang and J. M. Krueger
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USA.

It is hypothesized that interleukin-1 (IL-1) is involved in physiological sleep. If this hypothesis is correct, inhibition of IL-1 should attenuate sleep responses after sleep deprivation. We tested the effect of intracerebroventricular or intravenous injection of an IL-1 inhibitor, an IL-1 receptor fragment (IL-1RF), on sleep rebound after sleep deprivation in rabbits. Six hours of total sleep deprivation significantly increased non-rapid eye movement sleep (NREMS) and enhanced electroencephalogram slow-wave activity during NREMS. Intracerebroventricular treatment with the IL-1RF (50 micrograms) significantly attenuated the sleep responses after sleep deprivation. Furthermore, 1.0 mg/kg i.v. injection of the IL-1RF significantly suppressed spontaneous NREMS in rabbits that were not sleep deprived. However, intravenous administration of the IL-1RF (1.0 mg/kg) failed to attenuate the sleep responses following the 6-h sleep deprivation period. These results support the hypothesis that central pools of IL-1 are important for physiological sleep regulation.

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