AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 3 858-R863, Copyright © 1997 by American Physiological Society

ARTICLES

Effect of heat stress on LPS-induced fever and tumor necrosis factor

M. J. Kluger, K. Rudolph, D. Soszynski, C. A. Conn, L. R. Leon, W. Kozak, E. S. Wallen and P. L. Moseley
Lovelace Respiratory Research Institute, Albuquerque 87108, USA.

Exposure to heat stress leads to both short-term and long-term effects on morbidity. Male rats were exposed to a high ambient temperature of 40 degrees C, which resulted in biotelemetered core body temperature rising to approximately 42 degrees C. This treatment led to a marked enhancement in lipopolysaccharide (LPS)-induced fever at 24 h after exposure to heat stress. The increase in fever was accompanied by a significant suppression in the circulating concentration of tumor necrosis factor. Heat-shock protein-70 measured in liver was elevated by the heat exposure (but not further elevated by the injection of LPS). An enhanced fever to LPS and other inflammatory stimuli found in heat-stressed human subjects could explain the apparent increase in susceptibility to disease.

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