| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 3 905-R910, Copyright © 1997 by American Physiological Society
ARTICLES |
B. Gess, K. Schricker, M. Pfeifer and A. Kurtz
Institut fur Physiologie, Universitat Regensburg, Germany.
This study aimed to investigate the influence of acute tissue hypoxygenation on the expression of NO synthase (NOS) genes in vivo. To this end, male Sprague-Dawley rats were exposed either to 9% oxygen or to 0.1% carbon monoxide for 6 h, and mRNA levels of NOS-I, -II, and -III in kidneys, livers, lungs, and left and right heart ventricles were assayed by ribonuclease protection. For comparison, mRNA levels of erythropoietin were also measured in these tissues. NOS-III mRNA was highly abundant in all organs investigated. NOS-II mRNA was detected in lungs and hearts but not in kidneys and livers. NOS-I mRNA was found in kidneys, lungs, and hearts but not in livers. NOS-III mRNA levels were upregulated by hypoxia in all tissues examined, with the least effect (1.2-fold) in the left ventricle and the greatest effect (2.6-fold) in the lung. NOS-II mRNA was substantially downregulated in the ventricles by both treatments but not changed in the lung. NOS-I mRNA was upregulated by carbon monoxide in kidneys and lungs and by 9% oxygen in the lung. These findings suggest that NOS-III and possibly also NOS-I gene expression behave like oxygen-regulated genes, whereas the general effect of tissue hypoxygenation on NOS-II gene expression is less clear. Because NOS-III is primarily expressed in endothelial cells, a general upregulation of NOS in these cells may be of relevance for the regulation and maintenance of blood flow through hypoxic tissues.
This article has been cited by other articles:
|
|
 |
|
  E. B. Manukhina, H. F. Downey, and R. T. Mallet Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia. Experimental Biology and Medicine, April 1, 2006; 231(4): 343 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. P. Thompson and Y. Dong Chronic Hypoxia Decreases Endothelial Nitric Oxide Synthease Protein Expression in Fetal Guinea Pig Hearts Reproductive Sciences, September 1, 2005; 12(6): 388 - 395. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Sandner, K. H. Hofbauer, H. Tinel, A. Kurtz, H. C. Thiesson, P. D. Ottosen, S. Walter, O. Skott, and B. L. Jensen Expression of adrenomedullin in hypoxic and ischemic rat kidneys and human kidneys with arterial stenosis Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R942 - R951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Louzier, B. Raffestin, A. Leroux, D. Branellec, J. M. Caillaud, M. Levame, S. Eddahibi, and S. Adnot Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L926 - L937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Xi, D. Tekin, E. Gursoy, F. Salloum, J. E. Levasseur, and R. C. Kukreja Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H5 - H12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-H. Hofbauer, E. Schoof, A. Kurtz, and P. Sandner Inflammatory Cytokines Stimulate Adrenomedullin Expression Through Nitric Oxide-Dependent and -Independent Pathways Hypertension, January 1, 2002; 39(1): 161 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sengupta and B. Wasylyk Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2 Genes & Dev., September 15, 2001; 15(18): 2367 - 2380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Tahawi, N. Orolinova, I. G. Joshua, M. Bader, and E. C. Fletcher Physiological and Genomic Consequences of Intermittent Hypoxia: Selected Contribution: Altered vascular reactivity in arterioles of chronic intermittent hypoxic rats J Appl Physiol, May 1, 2001; 90(5): 2007 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Mann, A. Hartner, B. L. Jensen, K. F. Hilgers, K. Hocherl, B. K. Kramer, and A. Kurtz Acute upregulation of COX-2 by renal artery stenosis Am J Physiol Renal Physiol, January 1, 2001; 280(1): F119 - F125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Hampl and J. Herget Role of Nitric Oxide in the Pathogenesis of Chronic Pulmonary Hypertension Physiol Rev, October 1, 2000; 80(4): 1337 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Kudej, S.-J. Kim, Y.-T. Shen, J. B. Jackson, A. B. Kudej, G.-P. Yang, S. P. Bishop, and S. F. Vatner Nitric oxide, an important regulator of perfusion-contraction matching in conscious pigs Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H451 - H456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. White, R. E. McCullough, R. Dyckes, A. D. Robertson, and L. G. Moore Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H2069 - H2075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. GUILLOT, L. LIU, J. A. KUIVENHOVEN, J. GUAN, R. D. ROSENBERG, and W. C. AIRD Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression Physiol Genomics, March 13, 2000; 2(2): 77 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. KAKOKI, Y. HIRATA, H. HAYAKAWA, E. SUZUKI, D. NAGATA, A. TOJO, H. NISHIMATSU, N. NAKANISHI, Y. HATTORI, K. KIKUCHI, et al. Effects of Tetrahydrobiopterin on Endothelial Dysfunction in Rats with Ischemic Acute Renal Failure J. Am. Soc. Nephrol., February 1, 2000; 11(2): 301 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Schweda, F. C. Blumberg, A. Schweda, M. Kammerl, S. R. Holmer, G. A. J. Riegger, M. Pfeifer, and B. K. Kramer Effects of chronic hypoxia on renal renin gene expression in rats Nephrol. Dial. Transplant., January 1, 2000; 15(1): 11 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wolf, H. Castrop, A. Hartner, M. Goppelt-Strube, K. F. Hilgers, and A. Kurtz Inhibition of the Renin-Angiotensin System Upregulates Cyclooxygenase-2 Expression in the Macula Densa Hypertension, September 1, 1999; 34(3): 503 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gozal and E. Gozal Episodic hypoxia enhances late hypoxic ventilation in developing rat: putative role of neuronal NO synthase Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R17 - R22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Rahman and W. MacNee Role of transcription factors in inflammatory lung diseases Thorax, July 1, 1998; 53(7): 601 - 612. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
