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Am J Physiol Regul Integr Comp Physiol 273: R1569-R1571, 1997;
0363-6119/97 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 5 1569-R1571, Copyright © 1997 by American Physiological Society

ARTICLES

The imidazoline receptor in control of blood pressure by clonidine and allied drugs

D. J. Reis and J. E. Piletz
Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA.

Clonidine, moxonidine, and rilmenidine are centrally acting antihypertensive agents that lower arterial pressure by inhibiting the tonic activity of sympathoexcitatory neurons in the rostral ventrolateral medulla. Competing hypotheses have been put forward by different investigators to explain the sympathoinhibition evoked by "imidazoline drugs": either via central actions at alpha 2-adrenergic receptors or novel I1-imidazoline receptors. These different perspectives are presented in the accompanying reviews.


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