AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 273: R1669-R1675, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muneoka, K.
Right arrow Articles by Takahashi, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muneoka, K.
Right arrow Articles by Takahashi, K.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 5 1669-R1675, Copyright © 1997 by American Physiological Society

ARTICLES

Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring

K. Muneoka, M. Mikuni, T. Ogawa, K. Kitera, K. Kamei, M. Takigawa and K. Takahashi
Department of Neuropsychiatry, Kagoshima University Faculty of Medicine, Japan.

In this study, it has been clearly demonstrated that prenatal dexamethasone treatment (Dex; 0.05 mg/kg on gestational days 17, 18, and 19) resulted in the significant reductions of 5-hydroxytryptamine (5-HT) turnover in four brain regions, including the neocortex, hippocampus, hypothalamus, and midbrain + pons-medulla (M + P-M) but not in the striatum in the offspring at 3 and 14 wk of life, as well as dopamine turnover in the hypothalamus. [3H]paroxetine binding densities were increased in the hypothalamus and M + P-M at 14 wk of life, which corresponded to increased 5-HT contents in both regions. On the other hand, significantly lower norepinephrine contents in the neocortex and hippocampus were observed in the Dex group compared with the control group at 14 wk of life. In addition, the exposure to new environmental condition elevated blood corticosterone levels and enhanced behavioral activities to a greater extent in the Dex group than in controls at 7 wk of life, suggesting that elevated glucocorticoid levels during the pregnancy mimicked prenatal mild stress, producing developmental alterations in brain monoamine metabolism, endocrine response, and behavior in adult offspring.


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
A. E. Michael and A. T. Papageorghiou
Potential significance of physiological and pharmacological glucocorticoids in early pregnancy
Hum. Reprod. Update, September 1, 2008; 14(5): 497 - 517.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Dodic, A. Peers, K. Moritz, V. Hantzis, and E. M. Wintour
No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R343 - R350.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Dugovic, S. Maccari, L. Weibel, F. W. Turek, and a. O. Van Reeth
High Corticosterone Levels in Prenatally Stressed Rats Predict Persistent Paradoxical Sleep Alterations
J. Neurosci., October 1, 1999; 19(19): 8656 - 8664.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online