AJP - Regu AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 273: R1779-R1785, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramirez, I.
Right arrow Articles by Friedman, M. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramirez, I.
Right arrow Articles by Friedman, M. I.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 5 1779-R1785, Copyright © 1997 by American Physiological Society

ARTICLES

Satiety from fat? Adverse effects of intestinal infusion of sodium oleate

I. Ramirez, M. G. Tordoff and M. I. Friedman
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.

To determine whether damage to the intestinal mucosa by oleic acid causes the suppression of food intake observed in response to intraintestinal infusion of the fatty acid, we measured lactate dehydrogenase (LDH) activity, a marker for cell damage, in the intestinal lumen after intestinal infusion of fatty acid under conditions similar to those employed in studies of eating behavior. Infusions of 25 or 51 mM sodium oleate (neutralized oleic acid) markedly and rapidly increased LDH activity, whereas infusions of saline had little or no effect. Infusion of octanoate, which has been reported to be ineffective in reducing eating behavior, did not increase intestinal LDH activity relative to saline infusion. Similarly, infusion of ethyl oleate or free (nonneutralized) oleic acid neither increased luminal LDH activity nor suppressed food intake. Infusion of sodium oleate also produced a strong conditioned aversion to sucrose. The results strongly suggest that the suppression of food intake induced by intraintestinal infusion of sodium oleate is due to the injurious effects of this unphysiological form of the fatty acid.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Zafra, F. Molina, and A. Puerto
Learned flavor preferences induced by intragastric administration of rewarding nutrients: role of capsaicin-sensitive vagal afferent fibers
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R635 - R641.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Chen, Y. Yang, E. Braunstein, K. E. Georgeson, and C. M. Harmon
Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes
Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E916 - E923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Cox, W. J. Tyler, A. Randich, G. R. Kelm, S. S. Bharaj, R. J. Jandacek, and S. T. Meller
Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R604 - R610.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Hajnal, K. Takenouchi, and R. Norgren
Effect of Intraduodenal Lipid on Parabrachial Gustatory Coding in Awake Rats
J. Neurosci., August 15, 1999; 19(16): 7182 - 7190.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online