AJP - Regu AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 273: R1861-R1869, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yasuma, Y.
Right arrow Articles by Hallenbeck, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yasuma, Y.
Right arrow Articles by Hallenbeck, J. M.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 6 1861-R1869, Copyright © 1997 by American Physiological Society

ARTICLES

Effects of plasma from hibernating ground squirrels on monocyte-endothelial cell adhesive interactions

Y. Yasuma, R. M. McCarron, M. Spatz and J. M. Hallenbeck
Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA.

Adhesion and subsequent penetration of leukocytes into central nervous system ischemic tissue proceeds via a coordinated inflammatory mechanism involving adhesion molecules at the blood-endothelium interface. Mammalian hibernation is a state of natural tolerance to severely reduced blood flow-oxygen delivery (i.e., ischemia). Hibernating thirteen-lined ground squirrels were investigated in an attempt to identify factors responsible for regulating this tolerance. Since leukocytopenia is closely associated with entrance into hibernation, the role of leukocyte adhesion to endothelium in this phenomenon was examined. Intercellular adhesion molecule-1 (ICAM-1) is expressed by endothelium and regulates interactions with circulating leukocytes that may result in margination or extravasation. ICAM-1 expression by rat cerebral microvascular endothelial cells (EC) cultured with plasma from hibernating (HP) or nonhibernating (NHP) thirteen-lined ground squirrels was dose dependently increased by HP and, to a lesser extent, by NHP. Treatment of EC with HP coincidentally induced significantly greater increases in monocyte adhesion to EC (37.2%) than were observed with NHP (23.9%). Study of the effects of HP and NHP on monocyte adhesion to EC may identify mechanisms responsible for ischemic tolerance in hibernators and could lead to the development of novel therapeutic approaches to the treatment of stroke.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
H. V. CAREY, M. T. ANDREWS, and S. L. MARTIN
Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature
Physiol Rev, October 1, 2003; 83(4): 1153 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. B. Becker, M. L. Weisfeldt, M. H. Weil, T. Budinger, J. Carrico, K. Kern, G. Nichol, I. Shechter, R. Traystman, C. Webb, et al.
The PULSE Initiative: Scientific Priorities and Strategic Planning for Resuscitation Research and Life Saving Therapies
Circulation, May 28, 2002; 105(21): 2562 - 2570.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. Prendergast, D. A. Freeman, I. Zucker, and R. J. Nelson
Periodic arousal from hibernation is necessary for initiation of immune responses in ground squirrels
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1054 - R1062.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online