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Am J Physiol Regul Integr Comp Physiol 274: R23-R29, 1998;
0363-6119/98 $5.00
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Vol. 274, Issue 1, R23-R29, January 1998

PVN infusion of GLP-1-(7---36) amide suppresses feeding but does not induce aversion or alter locomotion in rats

Lance R. McMahon and Paul J. Wellman

Behavioral Neuroscience Program, Department of Psychology, Texas A&M University, College Station, Texas 77843-4235

Intracerebroventricular infusion of glucagon-like peptide-1-(7---36) amide (GLP-1) reduces feeding in rats, an effect that could be localized to the hypothalamic paraventricular nucleus (PVN). Intracerebroventricular GLP-1, however, may also induce conditioned taste aversion (CTA), thereby putting into question the specificity of the action of GLP-1 on feeding. The present experiments evaluated the action of PVN GLP-1 (0, 100, or 200 ng) on induction of CTA, on locomotion, and finally, on feeding and drinking in rats. PVN infusion of GLP-1 (100 or 200 ng) did not support the induction of CTA and did not reliably alter locomotion, but did suppress feeding and drinking. The present study suggests that GLP-1 infusions into the PVN reduce food and water intake without producing illness or disrupting locomotor behavior. These data, in conjunction with reports of increased feeding following antagonism of central GLP-1 receptors, support the notion that endogenous GLP-1, perhaps within the PVN, functions to suppress feeding in the rat.

peptides; paraventricular nucleus; gut-brain interactions; saccharin; food intake; satiety


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