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Am J Physiol Regul Integr Comp Physiol 274: R243-R247, 1998;
0363-6119/98 $5.00
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Vol. 274, Issue 1, R243-R247, January 1998

Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats

Yoshikazu Sato, Hiroki Horita, Toshie Kurohata, Hideki Adachi, and Taiji Tsukamoto

Department of Urology, Sapporo Medical University, School of Medicine, Sapporo 060, Japan

We investigated the influence of the extracellular nitric oxide (NO) level on male copulatory behavior. We confirmed the changes of nitrite (NO<SUP>−</SUP><SUB>2</SUB>) and nitrate (NO<SUP>−</SUP><SUB>3</SUB>) in the medial preoptic area (MPOA) by administration of the NO precursor L-arginine (L-Arg, 10 mM) or the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA, 10 mM) via a dialysis probe. NO<SUP>−</SUP><SUB>2</SUB> and NO<SUP>−</SUP><SUB>3</SUB> were measured simultaneously by an in vivo microdialysis method coupled with the Griess reaction. L-Arg induced significant elevations of extracellular NO<SUP>−</SUP><SUB>2</SUB> and NO<SUP>−</SUP><SUB>3</SUB>. L-NMMA significantly reduced NO<SUP>−</SUP><SUB>2</SUB> and NO<SUP>−</SUP><SUB>3</SUB> levels. We observed male copulatory behavior during infusion of L-Arg or L-NMMA. The mount rate of male rats significantly increased during infusion of L-Arg in the MPOA. Administration of L-NMMA reduced the mount rate. These findings suggested that the elevation of extracellular NO in the MPOA facilitates male copulatory behavior of rats, whereas the decrease of NO reduces their copulatory behavior.

mount; nitrite; nitrate; microdialysis; L-arginine


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