AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 274: R9-R18, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Berner, N. J.
Right arrow Articles by Heller, H. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berner, N. J.
Right arrow Articles by Heller, H. C.
Vol. 274, Issue 1, R9-R18, January 1998

Does the preoptic anterior hypothalamus receive thermoafferent information?

Nancy J. Berner1 and H. Craig Heller2

1 Department of Biology, The University of the South, Sewanee, Tennessee 37383-1000; and 2 Department of Biological Sciences, Stanford University, Stanford, California 94305-5020

The preoptic anterior hypothalamus (POAH) is considered the thermointegrative center of the mammalian brain. Studies on anesthetized and unanesthetized animals have demonstrated neurons in the POAH that respond to changes in both POAH temperature (TPOAH) and skin temperature (Ts). In these studies, however, electroencephalographic (EEG) activity was not monitored. Recent work has revealed the potential for arousal state selectivity of neurons combined with thermal influences on arousal state to create the appearance that cells are thermosensitive or thermoresponsive when in fact they may not be responding directly to temperature or to thermoafferent input. It is therefore necessary to reexamine the influence of central and peripheral temperature on POAH cells. In the present study, 66 POAH cells were recorded from urethan-anesthetized rats while EEG, TPOAH, and Ts were monitored. Seventy-five percent (41 of 55) of the cells were EEG state responsive; 22% (6 of 27) were TPOAH sensitive; and 33% (19 of 58) appeared to be Ts responsive. However, when EEG state changes were taken into account, none of the cells that appeared to be Ts responsive were responding to Ts within any uniform EEG state. All changes in their firing rates were associated with EEG state changes. This study raises a question as to whether or not peripheral temperature information is integrated in the POAH. Consideration should be given to the possibility that Ts information is integrated lower in the neuroaxis. Monitoring EEG is essential in studies attempting to characterize the integrative properties of POAH neurons of anesthetized or unanesthetized animals. This caveat applies not just to thermoregulatory studies but to investigations of other integrative functions of the hypothalamus and many other brain regions as well.

single-unit activity; thermoregulation; electroencephalograph; thermointegration; urethan anesthesia


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. A. Romanovsky
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R37 - R46.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. M. McAllen
The cold path to BAT
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R124 - R126.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Tanaka, N. C. Owens, K. Nagashima, K. Kanosue, and R. M. McAllen
Reflex activation of rat fusimotor neurons by body surface cooling, and its dependence on the medullary raphe
J. Physiol., April 15, 2006; 572(2): 569 - 583.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Nomoto, M. Ohta, S. Kanai, Y. Yoshida, S. Takiguchi, A. Funakoshi, and K. Miyasaka
Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R556 - R561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. M. McAllen
Preoptic thermoregulatory mechanisms in detail
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R272 - R273.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. A. Nunneley, C. C. Martin, J. W. Slauson, C. M. Hearon, L. D. H. Nickerson, and P. A. Mason
Changes in regional cerebral metabolism during systemic hyperthermia in humans
J Appl Physiol, February 1, 2002; 92(2): 846 - 851.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Kenney, J. G. Pickar, M. L. Weiss, C. S. Saindon, and R. J. Fels
Effects of midbrain and spinal cord transections on sympathetic nerve responses to heating
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1329 - R1338.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online