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Department of Physiology, College of Medicine, Northeastern Ohio Universities, Rootstown, Ohio 44272
Arterial
pressure (AP), heart rate (HR), cardiac sympathetic tonus (ST), and
parasympathetic tonus (PT) were determined in spontaneously
hypertensive rats (SHR, 8 male and 8 female) and Wistar-Kyoto
normotensive rats (WKY, 8 male and 12 female) before and after acute
exercise. Before exercise, hypertensive rats (regardless of gender) had
an increased ST (+15 beats/min), increased resting HR (+12 beats/min),
and decreased PT (
11 beats/min). Similarly, female rats
(regardless of strain) also had an increased ST (+15 beats/min),
increased resting HR (+39 beats/min), and decreased PT (14
beats/min). Hypertensive rats had a significant reduction in AP
(17 ± 3 mmHg), ST (26 beats/min), PT (7
beats/min), and HR (14 beats/min) after exercise. In contrast,
AP was not reduced in normotensive rats and ST (+18 beats/min) and HR
(+42 beats/min) were increased in female normotensive rats after
exercise. However, male normotensive rats had a postexercise reduction
in ST (14 beats/min) and HR (19 beats/min). In summary,
AP, ST, and resting HR were higher whereas PT was lower in hypertensive
vs. normotensive rats. Furthermore, females had a higher resting HR,
intrinsic HR, and ST and lower PT than male rats. These data
demonstrate that gender and the resting level of AP influence cardiac
autonomic regulation.
hypertension; blood pressure; heart rate; autonomic nervous system; spontaneously hypertensive rats; Wistar-Kyoto rats
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