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1 Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia 5000; and 2 Department of Geriatrics, St. Louis University and Geriatric Research Education and Clinical Center, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri 63104
To investigate the short-term effects of
insulin on feeding, 14 fasting, young adults received 150-min
euglycemic intravenous infusions of control (C), low-dose (LD, 0.8 mU · kg
1 · min1),
and high-dose (HD, 1.6 mU · kg1 · min1)
insulin and ate freely from a buffet meal during the last 30 min.
Steady-state preprandial plasma insulin concentrations were 5.9 ± 0.7 (C), 47 ± 2 (LD), and 95 ± 6 (HD) µU/ml and increased 56-59 µU/ml during the meal. No effect of treatment type on
hunger or fullness ratings, duration of eating, or the weight, energy content (1,053 ± 95 kcal, C; 1,045 ± 101 kcal, LD; 1,066 ± 107 kcal, HD; P = 0.9), and
composition of food eaten was observed. On a fourth study day, 12 of
the subjects received an intravenous infusion of glucose only (Glc)
that was identical to the glucose infusion on their HD insulin day.
Mean venous glucose concentration was 9.3 ± 0.5 mmol
[P < 0.001 vs. C (5.3 ± 0.1), LD (5.2 ± 0.2), and HD (5.2 ± 0.2)], and plasma
insulin increased to 45 ± 2.3 µU/ml at the start and 242 ± 36 µU/ml at the end of the meal. Energy intake during the meal was
(~15%) reduced (1,072 ± 97 kcal, C; 1,086 ± 102 kcal, LD;
1,088 ± 105 kcal, HD; 919 ± 115 kcal, Glc;
P < 0.05 Glc vs. C, LD, and HD).
Plasma insulin normally increases to ~100 µU/ml after a mixed meal
in lean subjects. Therefore, in the absence of altered blood glucose
concentrations, physiological concentrations of insulin are unlikely to
play a role in meal termination and the short-term control of appetite.
glucoprivation; feeding; hunger
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