AJP - Regu AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 274: R635-R644, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nishimura, M.
Right arrow Articles by Yoshimura, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nishimura, M.
Right arrow Articles by Yoshimura, M.
Vol. 274, Issue 3, R635-R644, March 1998

Benzamil blockade of brain Na+ channels averts Na+-induced hypertension in rats

Masato Nishimura1, Ken Ohtsuka1, Akira Nanbu1, Hakuo Takahashi2, and Manabu Yoshimura1

1 Department of Clinical and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto 602; and 2 Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Moriguchi City, Osaka 570, Japan

To determine the possible involvement of brain amiloride-sensitive Na+ channels in Na+-induced hypertension, we investigated the effects of benzamil hydrochloride, a specific blocker of these Na+ channels, on the acute pressor mechanisms of intracerebroventricular infusion of hypertonic NaCl and the continuous pressor mechanisms of Na+-induced chronic hypertension, such as deoxycorticosterone acetate-salt hypertensive or stroke-prone spontaneous hypertensive rats, and of non-Na+-induced hypertension, such as renovascular hypertensive rats. Intracerebroventricular preinjection with benzamil (1 or 10 nmol/kg) abolished the increase in mean arterial pressure, heart rate, abdominal sympathetic discharge, and plasma vasopressin concentration induced by an acute increase in cerebrospinal Na+ concentrations at intracerebroventricular infusion of 1.5 M hypertonic NaCl. Continuous intracerebroventricular infusion of benzamil (1 or 10 nmol · kg-1 · day-1) for 7 days attenuated Na+-induced chronic hypertension in both deoxycorticosterone acetate-salt and stroke-prone spontaneous hypertensive rats, accompanied by reduction of urinary excretion of vasopressin and norepinephrine but not in renovascular hypertensive rats. Intravenous infusion of benzamil (10 nmol · kg-1 · day-1) for 7 days affected neither arterial pressure nor urinary excretion of vasopressin and norepinephrine in either model of hypertension. Benzamil-blockable brain amiloride-sensitive Na+ channels are expected to function as one of the Na+ receptors in the brain and to be involved in the pressor mechanism of Na+-induced hypertension.

amiloride-sensitive sodium ion channels; deoxycorticosterone acetate-salt; stroke-prone spontaneously hypertensive rat; aortic ligation; sympathetic nervous system; arginine vasopressin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Wang, B. S. Huang, and F. H. H. Leenen
Brain sodium channels and ouabainlike compounds mediate central aldosterone-induced hypertension
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2516 - H2523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Q. H. Chen and G. M. Toney
AT1-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1844 - R1853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. S. Huang, H. Wang, and F. H. H. Leenen
Enhanced sympathoexcitatory and pressor responses to central Na+ in Dahl salt-sensitive vs. -resistant rats
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H1881 - H1889.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. F. Keep, X. Si, P. Shakui, S. R. Ennis, and A. L. Betz
Effect of amiloride analogs on DOCA-salt-induced hypertension in rats
Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H2215 - H2220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Nishimura, K. Ohtsuka, N. Iwai, H. Takahashi, and M. Yoshimura
Regulation of brain renin-angiotensin system by benzamil-blockable sodium channels
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1416 - R1424.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online