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on sleep are mediated by the type
I receptor
Department of Physiology and Biophysics, University of Tennessee, Memphis, Tennessee 38163
Interleukin-1
(IL-1) is a well
characterized sleep regulatory substance. To study receptor mechanisms
for the sleep-promoting effects of IL-1, sleep patterns were
determined in control and IL-1 type I receptor knockout (IL-1RI KO)
mice with a B6x129 background after intraperitoneal injections of
saline or murine recombinant IL-1. The IL-1RI KO mice had slightly
but significantly less sleep during the dark period compared with the
controls. IL-1 dose dependently increased non-rapid eye movement
sleep (NREMS) and suppressed rapid eye movement sleep (REMS) in the
controls. The IL-1RI KO mice did not respond to IL-1. In contrast,
the IL-1RI KO mice increased NREMS and decreased REMS after
administration of tumor necrosis factor-
(TNF-), another well
characterized sleep-promoting substance. These results
1) provide further evidence that
IL-1 is involved in sleep regulation,
2) indicate that the effects of
IL-1 on sleep are mediated by the type I receptor, and
3) suggest that TNF- is capable
of inducing sleep without the involvement of IL-1.
interleukin-1 receptor; knockout mice; tumor necrosis factor
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