| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pediatrics and Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, Colorado 80262
Although fish oil supplementation may
prevent the onset of diet-induced insulin resistance in rats, it
appears to worsen glycemic control in humans with existing insulin
resistance. In the present study, the euglycemic, hyperinsulinemic
(4× basal) clamp technique with
[3-3H]glucose and
2-deoxy-[1-14C]glucose
was used to directly compare the ability of fish oil to prevent and
reverse sucrose-induced insulin resistance. In study
1 (prevention study), male Wistar rats were fed a
purified high-starch diet (68% of total energy), high-sucrose diet
(68% of total energy), or high-sucrose diet in which 6% of the fat content was replaced by menhaden oil for 5 wk. In
study 2 (reversal study), animals were
fed the high-starch or high-sucrose diets for 5 wk and then the sucrose
animals were assigned to one of the following groups for an additional
5 wk: high starch, high sucrose, or high sucrose with 6% menhaden oil.
Rats fed the high-starch diet for 10 wk served as controls. In
study 3 (2nd reversal study), animals
followed a similar diet protocol as in study
2; however, the reversal period was extended to 15 wk.
In study 1, the presence of the fish
oil in the high-sucrose diet prevented the development of insulin
resistance. Glucose infusion rates (GIR,
mg · kg
1 · min1)
were 17.0 ± 0.9 in starch, 10.6 ± 1.7 in sucrose, and 15.1 ± 1.5 in sucrose with fish oil animals. However, in
study 2, this same diet was unable to
reverse sucrose-induced insulin resistance (GIR, 16.7 ± 1.4 in
starch, 7.1 ± 1.5 in sucrose, and 4.8 ± 0.9 in sucrose with
fish oil animals). Sucrose-induced insulin resistance was reversed in
rats that were switched back to the starch diet (GIR, 18.6 ± 3.0).
Results from study 3 were similar to
those observed in study 2. In summary,
fish oil was effective in preventing diet-induced insulin resistance
but not able to reverse it. A preexisting insulin-resistant environment
interferes with the positive effects of menhaden oil on insulin action.
liver; triglycerides; fish oil
This article has been cited by other articles:
|
|
 |
|
  Z. Vasanji, E. J. F. Cantor, D. Juric, M. Moyen, and T. Netticadan Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance Am J Physiol Cell Physiol, October 1, 2006; 291(4): C772 - C780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Davidoff, M. M. Mason, M. B. Davidson, M. W. Carmody, K. K. Hintz, L. E. Wold, D. A. Podolin, and J. Ren Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E718 - E724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, H. Cho, S. O'Malley, J. H. Y. Park, and S. D. Clarke Dietary Polyunsaturated Fats Regulate Rat Liver Sterol Regulatory Element Binding Proteins-1 and -2 in Three Distinct Stages and by Different Mechanisms J. Nutr., November 1, 2002; 132(11): 3333 - 3339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Peyron-Caso, M. Taverna, M. Guerre-Millo, A. Veronese, N. Pacher, G. Slama, and S. W. Rizkalla Dietary (n-3) Polyunsaturated Fatty Acids Up-Regulate Plasma Leptin in Insulin-Resistant Rats J. Nutr., August 1, 2002; 132(8): 2235 - 2240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Commerford, M. E. Bizeau, H. McRae, A. Jampolis, J. S. Thresher, and M. J. Pagliassotti Hyperglycemia compensates for diet-induced insulin resistance in liver and skeletal muscle of rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1380 - R1389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dutta, D. A. Podolin, M. B. Davidson, and A. J. Davidoff Cardiomyocyte Dysfunction in Sucrose-Fed Rats Is Associated With Insulin Resistance Diabetes, May 1, 2001; 50(5): 1186 - 1192. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Thresher, D. A. Podolin, Y. Wei, R. S. Mazzeo, and M. J. Pagliassotti Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1334 - R1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Kim, L. A. Nolte, P. A. Hansen, D.-H. Han, K. Kawanaka, and J. O. Holloszy Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R665 - R672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, M. Teran-Garcia, J. H. Y. Park, M. T. Nakamura, and S. D. Clarke Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay J. Biol. Chem., March 23, 2001; 276(13): 9800 - 9807. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
