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Am J Physiol Regul Integr Comp Physiol 274: R1260-R1267, 1998;
0363-6119/98 $5.00
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Vol. 274, Issue 5, R1260-R1267, May 1998

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function

M. T. Lin1, H. J. Tsay1, W. H. Su2, and F. Y. Chueh3

1 Department of Physiology and Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan 11221; 2 Department of Physiology, National Cheng-Kung University, Tainan, Taiwan 40101; and 3 Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan 70101, Republic of China

Experiments were carried out to determine the effects of altering the serotonin (5-HT) levels in the hypothalamus on thermoregulatory function in unanesthetized restrained rats. Local perfusion of the hypothalamus with dialysis solution containing 5-hydroxytryptophan (a 5-HT precursor), fluoxetine (a 5-HT reuptake inhibitor), or high potassium significantly increased both colonic temperature (Tco) and the extracellular concentrations of 5-HT in the hypothalamus. Reciprocally, both extracellular concentration of 5-HT in the hypothalamus and Tco were decreased with a dialysis solution containing tetrodotoxin (which blocks the voltage-dependent sodium channel), zero calcium concentration, or systemic administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 5-HT1A agonist). Intrahypothalamic administration of 8-OH-DPAT and (2,5-dimethoxy-4-iodophenyl)-2-aminopropane (a 5-HT2 agonist) produced hypothermic and hyperthermic effects, respectively. The results indicate that elevating the 5-HT levels in the hypothalamus activates postsynaptic 5-HT2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5-HT1A receptors in the hypothalamus reduces the endogenous 5-HT release and results in hypothermic effects.

thermoregulation; microdialysis


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