| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cardiovascular Center and Department of Internal Medicine, University of Iowa College of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242
Previous studies have demonstrated that the lateral parabrachial nucleus (LPBN) is an important site for descending modulation of baroreflex control of heart rate. In the present study it was hypothesized that the LPBN neurons may also modulate baroreflex control of arterial pressure and sympathetic nerve activity. In urethan-anesthetized rats, electrical or chemical activation of the LPBN produced a significant reduction in the magnitude of the baroreflex inhibition of mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) elicited by aortic depressor nerve stimulation. Chemical inactivation of the LPBN resulted in a small increase in baroreflex control of MAP, but baroreflex control of RSNA was not affected. The results suggest that LPBN neurons have little tonic influence over baroreflex control of MAP and RSNA in the anesthetized rat. When the LPBN is activated, however, LPBN neurons may function to reduce the capacity of the baroreflex to regulate sympathetically mediated increases in arterial pressure.
dorsolateral pons; descending modulation; aortic nerve stimulation; D,L-homocysteic acid
This article has been cited by other articles:
|
|
 |
|
  D. M. Baekey, T. E. Dick, and J. F. R. Paton Pontomedullary transection attenuates central respiratory modulation of sympathetic discharge, heart rate and the baroreceptor reflex in the in situ rat preparation Exp Physiol, July 1, 2008; 93(7): 803 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Blair and D. Mickelsen Activation of lateral parabrachial nucleus neurons restores blood pressure and sympathetic vasomotor drive after hypotensive hemorrhage Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R742 - R750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Dick, Y.-H. Hsieh, S. Morrison, S. K. Coles, and N. Prabhakar Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1121 - R1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Hayward, M. Castellanos, and P. W. Davenport Parabrachial neurons mediate dorsal periaqueductal gray evoked respiratory responses in the rat J Appl Physiol, March 1, 2004; 96(3): 1146 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Blair, R. L. Jaworski, A. Want, and D. T. Piekut Parabrachial nucleus modulates cardiovascular responses to blood loss Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1141 - R1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-B. Len and J. Y. H. Chan Glutamatergic projection to RVLM mediates suppression of reflex bradycardia by parabrachial nucleus Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1482 - H1492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Barman, G. L. Gebber, and H. Kitchens Rostral dorsolateral pontine neurons with sympathetic nerve-related activity Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H401 - H412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Hayward, A. P. Riley, and R. B. Felder alpha 2-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2336 - H2345. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
