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Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226; and Max Delbrück Center for Molecular Medicine, 13122 Berlin, Germany
Implanted optical fibers and
laser-Doppler flow measurement techniques were used for the sequential
measurement of regional renal blood flow in conscious rats to determine
the effects of an increase of daily NaCl intake on the renal cortical
blood flow and blood flow to the outer and inner medulla. Cortical
blood flow was increased significantly (32%) by the second day when NaCl intake was increased from 1 to 7 meq/day and was increased further
(50%) on the second day after a further elevation of NaCl intake to 13 meq/day. Blood flow to the outer and inner medulla was not changed as
NaCl intake was elevated. The increase in renal cortical flow was
closely associated with significant reductions in circulating
concentrations of ANG II from 31 to 16 pg/ml. Rats given a continuous
infusion of nonpressor doses of ANG II (5.0 ng · kg
1 · min1)
to maintain constant plasma concentrations of ANG II as sodium intake
was increased exhibited no increase of cortical flow. We conclude that
reductions of plasma ANG II associated with incremental increases of
daily sodium intake result in a rise of renal cortical flow. The
elevated blood flow to the renal cortex may enhance sodium excretion
and contribute to long-term sodium homeostasis.
angiotensin; cortical blood flow; medullary blood flow; sodium chloride intake
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