AJP - Regu AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 274: R1331-R1337, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smolich, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smolich, J. J.
Vol. 274, Issue 5, R1331-R1337, May 1998

NO modulates fetoplacental blood flow distribution and whole body oxygen extraction in fetal sheep

Joseph J. Smolich

Monash University Institute of Reproduction and Development, Clayton, Victoria 3168, Australia

It is unknown if nitric oxide (NO) influences the relative level of the left (LV) and right ventricular (RV) outputs, the blood flow distribution between the body and placenta, or whole body O2 extraction and O2 consumption in the fetus. To address these questions eight fetal lambs were chronically instrumented at 128-134 days gestation (term 147 days), and blood flows were measured with radioactive microspheres 3-4 days later at baseline and after inhibition of NO synthesis with Nomega -nitro-L-arginine (L-NNA, 10 and 25 mg/kg iv). L-NNA progressively reduced the combined ventricular output (P < 0.005) but did not alter the relative levels of the LV and RV outputs. Fetal body blood flow fell by 31% after 10 mg/kg L-NNA (P < 0.005), but a reduction in placental blood flow (P < 0.005) was smaller (20%) and not observed until 25 mg/kg L-NNA. Whole body O2 extraction increased by 71% after 10 mg/kg L-NNA (P < 0.005) and did change further at 25 mg/kg L-NNA, whereas whole body O2 consumption rose by 15% at 10 mg/kg L-NNA (P < 0.05) and returned to baseline at 25 mg/kg L-NNA. These results suggest that, as well as reducing the combined ventricular output, inhibition of fetal NO synthesis redistributes systemic blood flow toward the placenta and increases fetal body O2 extraction. The latter initially increases whole body O2 consumption and then maintains it at near baseline levels after a fall in placental perfusion.

fetus; cardiac output; blood flow; oxygen consumption


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich, J. P. Mynard, and D. J. Penny
Ductus arteriosus wave intensity analysis in fetal lambs: midsystolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R1171 - R1179.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich, J. P. Mynard, and D. J. Penny
Dynamic characterization and hemodynamic effects of pulmonary waves in fetal lambs using cardiac extrasystoles and beat-by-beat wave intensity analysis
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2009; 297(2): R428 - R436.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. B. Blood, M. Tiso, S. T. Verma, J. Lo, M. S. Joshi, I. Azarov, L. D. Longo, M. T. Gladwin, D. B. Kim-Shapiro, and G. G. Power
Increased nitrite reductase activity of fetal versus adult ovine hemoglobin
Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H237 - H246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich, J. P. Mynard, and D. J. Penny
Simultaneous pulmonary trunk and pulmonary arterial wave intensity analysis in fetal lambs: evidence for cyclical, midsystolic pulmonary vasoconstriction
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1554 - R1562.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Sanhueza, R. A. Riquelme, E. A. Herrera, D. A. Giussani, C. E. Blanco, M. A. Hanson, and A. J. Llanos
Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R776 - R783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich
NO supports right ventricular flow dominance and whole body O2 utilization in midgestation fetal lambs
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1016 - R1022.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online