AJP - Regu AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 274: R1762-R1768, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Keller-Wood, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Keller-Wood, M.
Vol. 274, Issue 6, R1762-R1768, June 1998

ACTH responses to CRF and AVP in pregnant and nonpregnant ewes

Maureen Keller-Wood

Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida 32610

During both ovine and human pregnancy plasma cortisol is increased. In human pregnancy the placenta secretes corticotropin-releasing factor (CRF), but pituitary responses to CRF are decreased. However, in ovine pregnancy there is no measurable placental secretion of CRF. This study tests for changes in pituitary responsiveness to CRF or AVP. Pregnant and nonpregnant ewes were infused with saline or CRF at three doses (3, 9, 45 µg/h), with or without coinfusion of AVP (9 µg/h). AVP infusion increased plasma AVP to ~250 pg/ml. CRF infusions increased plasma CRF from ~25 to 50, 150, and 850 pg/ml. ACTH was significantly increased by the infusion of AVP and by all infusions of CRF. Within-animal comparisons revealed a potentiation of the ACTH response to CRF in the presence of AVP. The ACTH responses to AVP and/or CRF were not different between pregnant and nonpregnant ewes. The results suggest that there is no change in pituitary responsiveness to CRF or AVP during ovine pregnancy.

adrenocorticotropin; corticotropin-releasing hormone; sheep; adrenal; cortisol; pituitary


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Hazard, M. Couty, and D. Guemene
Characterization of CRF, AVT, and ACTH cDNA and pituitary-adrenal axis function in Japanese quail divergently selected for tonic immobility
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1421 - R1429.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
S. F. Young and J. C. Rose
Attenuation of Corticotropin-Releasing Hormone and Arginine Vasopressin Responsiveness During Late-Gestation Pregnancy in Sheep
Biol Reprod, June 1, 2002; 66(6): 1805 - 1812.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online