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Am J Physiol Regul Integr Comp Physiol 274: R1829-R1833, 1998;
0363-6119/98 $5.00
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Vol. 274, Issue 6, R1829-R1833, June 1998

RAPID COMMUNICATION
Interleukin-1beta -converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia

William Burgess1, Gilles Gheusi2, Jianhua Yao3, Rodney W. Johnson3, Robert Dantzer2, and Keith W. Kelley1

Laboratories of 1 Immunophysiology and 3 Integrative Biology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801; and 2 Neurobiologie Integrative, Institut National de la Recherche Agronomique-Institut National de la Santé et de la Recherche Médicale, U394 Bordeaux, France

Interleukin-1beta (IL-1beta ) mediates many of the behavioral responses to infection and inflammation, and IL-1beta -converting enzyme (ICE) processes intracellular IL-1beta , leading to its maturation and secretion. Here we demonstrate that intracerebroventricular injections of lipopolysaccharide (LPS) produced a greater reduction in both food intake and food-motivated behavior in wild-type compared with ICE-deficient (ICE -/-) mice. This defect occurred although ICE -/- mice were able to fully respond to intracerebroventricular injections of IL-1beta . In contrast, ICE -/- mice remained fully responsive to intraperitoneal injections of LPS. These results indicate that brain, but not peripheral, IL-1beta plays a critical role in the depression in food intake that occurs during inflammation.

lipopolysaccharide; feeding


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